Evaluation of Alternative Transfusion Triggers in Hemodynamically Stable, Non-Ventilated Cancer Patients

Ardak Arynov107 enrolled

Overview

This is a prospective, single-center observational study conducted at the Kazakh Institute of Oncology and Radiology. The study included 107 clinically stable adult patients with cancer who required red blood cell transfusion based on a restrictive hemoglobin threshold. The aim of the study was to evaluate alternative physiological indicators of transfusion need and effectiveness. Measurements included oxygen extraction ratio (O₂ER), central venous oxygen saturation (ScvO₂), partial pressure of oxygen in central venous blood (PvO₂), arterio-venous oxygen difference (A-VO₂diff), lactate, and veno-arterial carbon dioxide difference (ΔCO₂). These parameters were assessed before and one hour after transfusion. For data analysis, patients were stratified into two groups based on their baseline O₂ER (≤35.4% and \>35.4%) to evaluate whether higher O₂ER is associated with more pronounced physiological response to transfusion.

Study Type

OBSERVATIONAL

Enrollment

107

Conditions

Anemia Blood Transfusion Cancer Hemoglobin Alternative Physiological Transfusion Triggers

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult cancer patients (age 18 years or older) * Hemodynamically stable * Not requiring any form of respiratory support * Presence of a central venous catheter inserted into the superior vena cava Exclusion Criteria: * Hemodynamic instability requiring inotropic or vasopressor support * Active bleeding * Shock of any etiology * Patient refusal to participate in the study * Hematological malignancies * Age under 18 years * Pregnancy