The incidence of stroke-heart syndrome following acute stroke, which encompasses both acute ischemic stroke and acute intracerebral hemorrhage, is notably high and is strongly associated with increased mortality and poor outcomes in stroke patients. However, the underlying mechanisms remain unclear, and there are currently no effective prevention or treatment strategies. This study aims to elucidate the neuro-humoral mechanisms of stroke-heart syndrome through multimodal imaging and multi-omics blood analysis. Additionally, it seeks to observe the progression of stroke-heart syndrome and its impact on functional outcomes, cognitive abilities, and emotional issues post-stroke. The research is expected to uncover novel blood biomarkers and brain network mechanisms associated with stroke-heart syndrome, providing potential targets and theoretical foundations for pharmacological treatments or physical interventions. Furthermore, it aims to establish a risk early-warning system for major cardiovascular complications post-stroke, enabling early identification, early intervention, and integrated brain-heart management to improve clinical outcomes for stroke patients.
Study Type
OBSERVATIONAL
Enrollment
658
Department of Neurology, Tongji hospital, Tongji medical college, Huazhong University of Science and Technology
Wuhan, Hubei, China
RECRUITINGblood high-sensitivity cardiac troponin level
a marker of acute myocardial injury
Time frame: within 48 hours and at 72 hours after stroke onset
left ventricular ejection fraction
measured by transthoracic echocardiography; a marker of ventricular dysfunction and heart failure
Time frame: within 1 week after stroke onset
blood N-terminal pro-brain natriuretic peptide (NT-proBNP) level
a marker of ventricular dysfunction and heart failure
Time frame: within 1 week after stroke onset
functional outcome
measured by modified Rankin scale (mRS), a 7-level ordinal scale (scores 0-6) used to assess global disability after stroke. Higher scores indicate worse functional outcome.
Time frame: 3 months and 1 year after stroke onset.
death
Time frame: 1 month, 3 months and 1 year after stroke onset
post-stroke cognitive impairment
measured by Montreal Cognitive Assessement (MoCA), a widely used screening tool designed to detect mild cognitive impairment and dementia. MoCA score range: 0-30, higher scores indicate better cognitive function.
Time frame: 3 months and 1 year after stroke onset.
post-stroke depression
measured by Hamilton depression rating scale (HAMD), a widely used clinician-administered tool for assessing the severity of depression. HAMD score range: 0-52. Higher scores indicate higher depression severity.
Time frame: 3 months and 1 year after stroke onset.
post-stroke anxiety
measured by Hamilton anxiety rating scale (HAMA), a clinician-administered tool to assess the severity of anxiety symptoms. HAMA score range: 0-56. Higher scores indicate higher anxiety severity.
Time frame: 3 months and 1 year after stroke onset.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.