The goal of this clinical trial is to develop a human laboratory model of resilience in people with opioid use disorder (OUD). The investigators aim to learn if objective tasks that measure cognitive, emotional, and control aspects of resilience match up with self-reported resilience during stress and non-stress situations.
This study is an outpatient, within-subject, randomized controlled trial designed to develop and validate a novel laboratory-based model for assessing resilience in individuals with opioid use disorder (OUD). The study employs a dual-condition design where participants complete two experimental sessions administered in a randomized order: one under a stress condition and under a non-stress condition. In each session, participants will perform a series of standardized laboratory tasks aimed at evaluating cognitive, emotional, and control aspects of resilience. Objective measures (e.g., task performance data and physiological indices) and subjective ratings of stress reactivity will be collected to capture both behavioral and self-perceived responses.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
125
This intervention uses the Maastricht Acute Stress Test (MAST) to induce an acute stress response. Participants are exposed to standardized stress tasks while performing laboratory-based assessments of cognitive, emotional, and control aspects of resilience.
In this control intervention, participants complete the same battery of laboratory tasks without exposure to the acute stressor.
Johns Hopkins University Bayview Medical Campus
Baltimore, Maryland, United States
Self-Reported Trait Resilience as assessed by Connor-Davidson Resilience Scale 25 (CD-RISC-25)
Instrument: Connor-Davidson Resilience Scale 25 Score Range: 0-100 Interpretation: Higher scores indicate greater resilience.
Time frame: Immediately after completing the task
Cognitive Flexibility: Stroop Color-Word Test reaction time
Instrument: Stroop Color-Word Test Unit: Milliseconds (ms) Interpretation: Higher values = slower performance (worse)
Time frame: Immediately after completing the task
Emotional Flexibility: Emotional Stroop Task reaction time
Instrument: Emotional Stroop Task Unit: Milliseconds (ms) Interpretation: Higher values = slower performance (worse).
Time frame: Immediately after completing the task
Perceived Controllability (Controllable) assessed by Social Controllability Task (SCT)
Instrument: Social Controllability Task Description: Participants ratings on a 0-100% sliding scale. Interpretation: Higher scores indicate greater perceived control.
Time frame: Immediately after completing the task
Subjective Effects of Stress as assessed by the Subjective Effects Visual Analog Scale (VAS) Battery
Instrument: Subjective Effects Visual Analog Scale (VAS) Battery Instrument: VAS (0-100 mm) Interpretation: Higher scores indicate greater intensity of each subjective state.
Time frame: Immediately after completing the task
Heart Rate
Unit: Beats per minute (bpm) Interpretation: Higher = increased arousal
Time frame: Immediately after completing the task
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Systolic Blood Pressure
Unit: mmHg Interpretation: Higher = greater pressure.
Time frame: Immediately after completing the task
Diastolic Blood Pressure
Unit: mmHg Interpretation: Higher = greater pressure.
Time frame: Immediately after completing the task
Opioid Demand Breakpoint as assessed by the Hypothetical Purchase Task
Instrument: Hypothetical Purchase Task Range: $0-$500 Interpretation: Higher = greater demand.
Time frame: Immediately after completing the task