TTVR-AHI is a multicenter, retrospective registry including heart failure patients displaying a severe and symptomatic tricuspid regurgitation (TR), deemed non-eligible to cardiac surgery and therefore treated with transcatheter tricuspid valve replacement (TTVR) devices. This substudy of the main registry will focus on those with post-procedural acute hemodynamic instability (AHI).
TTVR-AHI is an international, multicenter, retrospective registry collecting routine clinical and echocardiographic data, on top of a dedicated analysis of the preprocedural CT-scan using Laralab® software. Patients with AHI will be compared to a control group without AHI, composed of individuals implanted with TTVR at Columbia University Irving Medical Center. In this substudy at Columbia, the investigators aim to describe AHI incidence, its clinical presentation, its impact on prognosis, and the predictors of its occurrence.
Study Type
OBSERVATIONAL
Enrollment
140
Columbia University Medical Center
New York, New York, United States
Mortality Rate
The prognosis of AHI after TTVR will be measured as the rate of all cause mortality in comparison to the control group.
Time frame: 1 Year
Number of Participants with Coronary Artery Disease (CAD)
Provide a multimodality description of the AHI population in comparison to the control group by defining the specificities of the AHI population. The number of participants with CAD will be reported.
Time frame: Baseline (Day 0)
Number of Participants with Right Ventricular (RV) Dysfunction
Provide a multimodality description of the AHI population in comparison to the control group by defining the specificities of the AHI population. The number of participants with RV dysfunction will be reported.
Time frame: Baseline (Day 0)
Number of Participants with Pulmonary Hypertension
Provide a multimodality description of the AHI population in comparison to the control group by defining the specificities of the AHI population. The number of participants with pulmonary hypertension will be reported.
Time frame: Baseline (Day 0)
Number of Participants with Primary Left Ventricular Cardiomyopathy
Provide a multimodality description of the AHI population in comparison to the control group by defining the specificities of the AHI population. The number of participants with primary left ventricular cardiomyopathy will be reported.
Time frame: Baseline (Day 0)
Number of Participants with Post-Procedural Fever
The number of participants with post-procedural fever will be reported and used to define the factors associated with the occurrence of AHI after TTVR in multivariable analysis.
Time frame: Within 48 hours after the procedure
Number of Participants with Post-procedural Inflammatory Response
The number of participants with post-procedural inflammatory response will be reported and used to define the factors associated with the occurrence of AHI after TTVR in multivariable analysis.
Time frame: Within 48 hours after the procedure
Number of Participants with AHI
Number of Participants with AHI among all the population screened
Time frame: Within 24 hours after the procedure
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.