Bilirubin Levels to Diagnose Appendicitis and Predict Appendiceal Perforation

Nepalese Army Institute of Health Sciences98 enrolled

Overview

The goal of this study is to learn if serum bilirubin levels can aid in the diagnosis of acute appendicitis and predict appendiceal perforation

The study aims to assess hyperbilirubinemia: serum direct, indirect and total bilirubin to enhance the diagnostic accuracy of acute appendicitis. Also it aims to analyze different patient variables such as age, gender, duration of symptoms, leukocyte and neutrophil count, Alvarado score, presence of fever, nausea \& vomiting, peritonitis alongside serum total bilirubin level in patients with appendicitis and assess which variables can be taken as independent factors to predict appendiceal perforation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acute Appendicitis Appendicitis Perforated

Interventions

Non-interventionalOTHER

Non-interventional study

Eligibility

Sex: ALLMin age: 5 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients of age group above 5 years with acute appendicitis undergoing appendectomy with written informed consent. Exclusion Criteria: * Patients with appendicular lump. * Patients with acute and chronic liver diseases like acute hepatitis, hemolytic disease, Gilbert's syndrome, Dubin-Johnson syndrome, alcoholic liver disease. * Acquired or Congenital Biliary Disease. * History of Hepatotoxic drugs.

Locations (1)

Shree Birendra Hospital

Kathmandu, Bagmati, Nepal

Outcomes

Primary Outcomes

Perforated appendix

Perforated appendicitis was confirmed intraoperatively by the surgeon and at histological analysis of the specimen by the rupture of appendiceal wall to the serosa. Those with gangrenous walls were also taken as perforated.

Time frame: Presentation to hospital till perioperative period

Data from ClinicalTrials.gov

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