Evaluation of the Clinical Relationship Between Procalcitonin Level and Bacteremia Agent in Intensive Care Unit Patients

Gulhane Training and Research Hospital1,529 enrolled

Overview

In intensive care units, sepsis, which can be defined as bacteremia and the irregular and uncontrolled inflammatory response to it, is one of the most important causes of mortality. Early recognition of sepsis and appropriate antibiotic use for the causative agent is one of the most important steps in the fight against sepsis. Procalcitonin (PCT) is a calcitonin precursor peptide and has been reported to predict bacteremia early. While the PCT concentration level is negligible in healthy individuals, it has been shown to increase especially in bacterial infections, sepsis, trauma and burns. In our study, our aim is to determine whether there is a relationship between serum PCT concentration levels taken within 24 hours according to the time of the sample taken for blood culture with growth in patients followed up in our Internal Intensive Care Unit.

Study Type

OBSERVATIONAL

Enrollment

1,529

Conditions

Sepsis Septic Bacteremia and Sepsis Intensive Care Medicine Procalcitonin

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * Positive blood culture during their follow up * Patients over 18 years of age Exclusion Criteria: * Those under the age of 18 * Those who have had surgery or trauma in the last 72 hours * Those with a history of autoimmune disease, chronic renal failure * Patients admitted to intensive care due to acute pancreatitis, pregnancy, burns. * Patients with incomplete data.

Outcomes

Primary Outcomes

Correlation of serum PCT levels measured within 24 hours of culture in intensive care patients with bacteremia and the pathogen type (Gram-positive, Gram-negative, fungal) in the culture result.

Time frame: In patients with positive blood cultures, serum PCT values studied within the first 24 hours from the time the culture sample was taken will be evaluated retrospectively.

Secondary Outcomes

Diagnostic power of PCT levels in distinguishing Gram-negative, Gram-positive and fungal infections

Time frame: serum PCT values studied within the first 24 hours from the time the culture sample