This is an observational study tracking families and offspring of three cohorts from the 1986 Da Qing study: newly diagnosed diabetes, impaired glucose tolerance, and normoglycemia groups. Based on the original participants, the study will further include their spouses, first to third-generation offspring, and spouses of the offspring. General demographic information will be collected, and anthropometric measurements will be refined. A structured questionnaire will be used to gather disease history, family history of diabetes, and related information. Comprehensive diabetes-related laboratory screening and complication assessments will be conducted. A standardized biobank will be established, including blood and urine samples from the Da Qing Offspring Study, to support future research on epigenetics, metabolomics, and other mechanisms.
Study Type
OBSERVATIONAL
Enrollment
5,000
Dietary intervention: 30kcal energy intake per kilogram of body weight per day, increase vegetable intake, control sugar and alcohol intake, encourage overweight and obese people to lose weight, lose 0.5-1kg per month until the weight reaches the target. Exercise intervention: Appropriate physical activity in spare time, 30-40 minutes per day, 5 times a week.
China-Japan Friendship hospital
Beijing, Beijing Municipality, China
Cumulative incidence rate of diabetes
This study statistically analyzed the cumulative incidence rate of diabetes at the end of the study through interview, medical record review, physical examination
Time frame: Through study completion, an average of about 1.5 years
weight
The subject's weight is recorded and the results are reported in kilograms.
Time frame: Through study completion, an average of about 1.5 years
waist circumference
The subjects' waist circumference was recorded and the waist circumference results were reported in centimeters.
Time frame: Through study completion, an average of about 1.5 years
Height
The subject's height was recorded, and the results were recorded in centimeters.
Time frame: Through study completion, an average of about 1.5 years
Exercise frequency and intensity
The subjects' daily exercise frequency and intensity were recorded.
Time frame: Through study completion, an average of about 1.5 years
Coronary heart disease incidence
This study statistically analyzed the incidence of coronary heart disease at the end of the study through interview, medical record review, physical examination
Time frame: Through study completion, an average of about 1.5 years
all-cause deaths
This study counted all-cause deaths at the end of the study through death certificate, medical record review, family interview
Time frame: Through study completion, an average of about 1.5 years
incidence of diabetic peripheral neuropathy
This study statistically analyzed the incidence of diabetic peripheral neuropathy at the end of the study through interview, medical record review, physical examination
Time frame: Through study completion, an average of about 1.5 years
other cause mortality
This study statistically analyzed other cause mortality at the end of the study through death record, medical record review, family interview
Time frame: Through study completion, an average of about 1.5 years
cardiovascular mortality rate
This study statistically analyzed the cardiovascular mortality rate at the end of the study through death certificate, medical record review, family interview
Time frame: Through study completion, an average of about 1.5 years
incidence of blindness
This study statistically analyzed the incidence of blindness at the end of the study through interview, medical record review, physical examination
Time frame: Through study completion, an average of about 1.5 years
Diabetic retinopathy incidence
This study statistically analyzed the incidence of diabetic retinopathy at the end of the study through interview, medical record review, physical examination
Time frame: Through study completion, an average of about 1.5 years
Diabetic nephropathy incidence
This study statistically analyzed the incidence of diabetic nephropathy at the end of the study through interview, medical record review, physical examination
Time frame: Through study completion, an average of about 1.5 years
Peripheral vascular disease incidence
This study statistically analyzed the incidence of peripheral vascular disease at the end of the study through interview, medical record review, physical examination
Time frame: Through study completion, an average of about 1.5 years
Heart failure incidence
This study statistically analyzed the incidence of heart failure at the end of the study through interview, medical record review, physical examination
Time frame: Through study completion, an average of about 1.5 years
Stroke incidence
This study statistically analyzed the incidence of stroke at the end of the study through interview, medical record review, physical examination
Time frame: Through study completion, an average of about 1.5 years
dietary habits
The subjects' eating habits and dietary preferences were assessed through patient interviews.
Time frame: Through study completion, an average of about 1.5 years
health-related quality of life
The EuroQol questionnaire or health status questionnaire was administered through patient interviews to assess the subjects' health-related quality of life.
Time frame: Through study completion, an average of about 1.5 years
blood pressure
During the visit, the subjects' systolic and diastolic blood pressures were measured at rest by physical examination. The measurements were performed twice and the average was taken.
Time frame: Through study completion, an average of about 1.5 years
blood sugar
Blood samples were collected from the subjects at 1 hour and 2 hours after the steamed bread meal when they were fasting. The blood samples were used to test blood sugar levels and blood lipids, including total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol.
Time frame: Through study completion, an average of about 1.5 years
blood lipid
Venous blood was collected from the subjects in a fasting state. The blood samples were used to test blood lipid status, including total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol.
Time frame: Through study completion, an average of about 1.5 years
skin AGE
The skin AGE of the subjects was measured by physical examination. After cleaning the inner skin of the forearm, the AGE Reader probe was gently placed on the skin surface, the excitation light was emitted and the fluorescence intensity was recorded. The results were repeated 3 times and the average value was taken.
Time frame: Through study completion, an average of about 1.5 years
Tidal Volume
The subjects were assessed for Tidal Volume, which reflects the ventilation efficiency in the basic breathing state. Tidal Volume is measured in liters.
Time frame: Through study completion, an average of about 1.5 years
Functional Residual Capacity
Subjects were assessed for Functional Residual Capacity, which reflects lung capacity. Functional Residual Capacity is measured in liters.
Time frame: Through study completion, an average of about 1.5 years
Forced Vital Capacity
The subjects were assessed for Forced Vital Capacity, which reflects the overall ventilation capacity of the lungs. Forced Vital Capacity is measured in liters.
Time frame: Through study completion, an average of about 1.5 years
Forced Expiratory Volume in 1 second
The subjects were assessed for Forced Expiratory Volume in 1 second, which reflects respiratory reserve capacity. Forced Expiratory Volume in 1 second is measured in liters.
Time frame: Through study completion, an average of about 1.5 years
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