Hip fracture is a common and severe disease in elderly patients. The question of the study is whether elderly patients with severe osteopenia have significantly lower levels of the collagen-binding protein Hsp47 than relatively mobile patients due to advanced immobility before the fracture, and whether they participants have a similar risk of VTE to the normal population despite having had a hip fracture and surgery.
In this study, the investigators aimed to prospectively measure the Hsp 47 gene expression levels in patients scheduled for surgery due to intertrochanteric femur fracture and healthy volunteers in the same age group and compare the results with the literature. Also the complications prior or after surgery will be compared.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
90
Each subject analysed for SERPİNH1 and ROCK1 gene exppression
Prof Dr emil Tascıoglu City Hospital
Istanbul, Şişli, Turkey (Türkiye)
HSP 47
HSP 47 (SERPİNH1, ROCK1) gene expression analysis
Time frame: Gene expression analysis will be performed once samples are collected from all participants.
Thromboembolie
Thromboembolic events
Time frame: from fracture occur up to one year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.