The goal of this study (interventional clinical research not involving a health product) is to assess the prevalence of subclinical coronary atherosclerosis diagnosed by coronary CT angiography in heart failure patients in primary prevention, across different levels of cardiovascular risk defined by coronary artery calcium (CAC) score percentiles (based on data from the MESA study): low risk (≤25th percentile for age, sex, and ethnicity), intermediate risk (25th \< CAC ≤ 75th percentile), and high risk (\>75th percentile). The Patients will attend an on-site visit at inclusion (and must undergo a coronary CT angiography within 6 months following this visit), will be contacted by phone at 1 year and 2 years, and will return for an on-site visit at 30 months.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
600
Coronary CT scan with CAC score measurement (on the same day or within 6 months after the inclusion visit).
CHU Dijon Bourgogne
Dijon, France
RECRUITINGCHRU Lille
Lille, France
NOT_YET_RECRUITINGHospices Civils de Lyon
Lyon, France
RECRUITINGHôpital de la Conception, AP-HM
Marseille, France
NOT_YET_RECRUITINGCHU Nantes
Nantes, France
RECRUITINGHôpital de la Pitié-Salpêtrière, AP-HP
Paris, France
RECRUITINGHôpital Saint-Antoine, AP-HP
Paris, France
RECRUITINGCHU Rennes
Rennes, France
RECRUITINGCHU Strasbourg
Strasbourg, France
RECRUITINGPresence of subclinical coronary atherosclerosis
The criterion defining the presence of subclinical coronary atherosclerosis is the presence of at least one coronary stenosis greater than 50% in a main artery on coronary CT angiography
Time frame: At the time of performing the coronary CT scan
Identification of factors associated with the presence or absence of subclinical coronary atherosclerosis (coronary stenosis > 50% on coronary CT scan).
The anthropometric data collected as part of the current study will be comparable to the data collected as part of the SAFIR study
Time frame: 30 months
Identification of factors associated with the presence or absence of subclinical coronary atherosclerosis (coronary stenosis > 50% on coronary CT scan).
The clinic data collected as part of the current study will be comparable to the data collected as part of the SAFIR study
Time frame: 30 months
Identification of factors associated with the presence or absence of subclinical coronary atherosclerosis (coronary stenosis > 50% on coronary CT scan).
The drug treatments collected as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with the presence or absence of subclinical coronary atherosclerosis (coronary stenosis > 50% on coronary CT scan).
The genetic data collected as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with the presence or absence of subclinical coronary atherosclerosis (coronary stenosis > 50% on coronary CT scan).
The biological data collected as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with the presence or absence of subclinical coronary atherosclerosis (coronary stenosis > 50% on coronary CT scan).
Arterial Doppler ultrasound of the carotid arteries and lower limbs as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with the presence or absence of subclinical coronary atherosclerosis (coronary stenosis > 50% on coronary CT scan).
Pulse wave velocity measured by the pOpmeter as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with the presence or absence of subclinical coronary atherosclerosis (coronary stenosis > 50% on coronary CT scan).
Hepatic steatosis as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with the presence or absence of subclinical coronary atherosclerosis (coronary stenosis > 50% on coronary CT scan).
Hepatic fibrosis as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with the presence or absence of subclinical coronary atherosclerosis (coronary stenosis > 50% on coronary CT scan).
Nutritional data as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with the presence or absence of subclinical coronary atherosclerosis (coronary stenosis > 50% on coronary CT scan).
Physical activity as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with the presence or absence of subclinical coronary atherosclerosis (coronary stenosis > 50% on coronary CT scan).
Quality of life as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with a coronary calcium score less than or equal to the 25th percentile
The anthropometric data collected as part of the current study will be comparable to the data collected as part of the SAFIR study
Time frame: 30 months
Identification of factors associated with a coronary calcium score less than or equal to the 25th percentile
The clinic data collected as part of the current study will be comparable to the data collected as part of the SAFIR study
Time frame: 30 months
Identification of factors associated with a coronary calcium score less than or equal to the 25th percentile
The drug treatments collected as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with a coronary calcium score less than or equal to the 25th percentile
The genetic data collected as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with a coronary calcium score less than or equal to the 25th percentile
The biological data collected as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with a coronary calcium score less than or equal to the 25th percentile
Arterial Doppler ultrasound of the carotid arteries and lower limbs as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with a coronary calcium score less than or equal to the 25th percentile
Pulse wave velocity measured by the pOpmeter as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with a coronary calcium score less than or equal to the 25th percentile
Hepatic steatosis as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with a coronary calcium score less than or equal to the 25th percentile
Hepatic fibrosis as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with a coronary calcium score less than or equal to the 25th percentile
Nutritional data as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with a coronary calcium score less than or equal to the 25th percentile
Physical activity as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Identification of factors associated with a coronary calcium score less than or equal to the 25th percentile
Quality of life as part of the current study will be comparable to the data collected as part of the SAFIR study.
Time frame: 30 months
Study of the association between the characteristics of coronary atheroma plaque on coronary CT and major cardiovascular events at 30 months.
Semi-quantitative visual quantification of coronary stenoses on CT coronary angiography according to the CAD-RADS v2.0 classification and visual characterization of high-risk plaque features (vulnerability).
Time frame: 30 months
Study of the association between the characteristics of coronary atheroma plaque on coronary CT and major cardiovascular events at 30 months.
Quantification of total coronary atherosclerotic plaque, calcified and non-calcified, and by artery
Time frame: 30 months
Study of the association between the presence of subclinical atherosclerosis (coronary stenosis > 50% on CT coronary angiography) and major cardiovascular events at 30 months
Assess the association between the presence of significant coronary stenosis (\>50% on a major artery) on coronary CT and the following major cardiovascular events: * Acute coronary syndrome or myocardial infarction * Coronary revascularization: angioplasty or bypass * Ischemic stroke * Carotid endarterectomy * Revascularization of a lower limb artery: angioplasty or bypass * Amputation related to PAD * Cardiovascular death
Time frame: 30 months
Study of the association between the percentile of the coronary calcium score and major cardiovascular events and overall mortality at 30 months
Assess the occurrence of major cardiovascular events and mortality according to the percentile of the coronary calcium score.
Time frame: 30 months
Study of the association between arterial stiffness and major cardiovascular events and overall mortality at 30 months.
Assess the occurrence of major cardiovascular events and mortality according to the measurement of arterial stiffness evaluated by pulse wave velocity measured with the pOpmeter
Time frame: 30 months
Study of the association between the presence of hepatic steatosis and major cardiovascular events and overall mortality at 30 months
Evaluer la survenue des événements cardiovasculaires majeurs et la mortalité en fonction de la stéatose hépatique
Time frame: 30 months
Study of the association between the presence of liver fibrosis and major cardiovascular events and all-cause mortality at 30 months
Assess the occurrence of major cardiovascular events and mortality according to the presence of liver fibrosis
Time frame: 30 months
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