A Prospective, Single-center, Open-label Clinical Study to Evaluate the Safety and Efficacy of Inhaled BMD003(CFTR mRNA) in Chinese Adult Patients With Cystic Fibrosis

Inclusion Criteria: Patients must meet all of the following inclusion criteria to be included in this study: 1. Gender not limited, 18 years old and above (including threshold values); 2. The subjects themselves agree to participate in the study and sign an informed consent form 3. Diagnosed with cystic fibrosis (CF); 4. According to the investigators' assessment, the subject's cystic fibrosis disease is clinically stable; 5. During screening, the subject's body mass index (BMI) is ≥ 17.5 kg/m ² and their weight is ≥ 40 kg; 6. Forced Expiratory Volume in 1 second (FEV1) is expected to be ≥ 40% of the normal value; 7. Resting oxygen saturation (SpO2) ≥ 92%; 8. Quit smoking for at least 2 years; 9. The subjects are willing and able to comply with the scheduled visits, treatments, laboratory tests, contraception requirements, and other study procedures. Exclusion Criteria: Individuals who meet any of the following criteria are not eligible for inclusion in this study: 1. Acute respiratory infection, acute exacerbation of lung disease, clinically significant hemoptysis (\>30 mL, or as determined by the investigator), or changes in respiratory medications (including antibiotics, oral steroids, etc.) used to treat CF occurred within 4 weeks prior to the first administration; 2. Infected with highly virulent bacteria associated with accelerated decline in lung function and/or shortened survival time (e.g. Burkholderia cepacia, Mycobacterium abscesses). For subjects with a positive culture history, they can be considered uninfected according to the following guidelines: All culture results obtained in the past 12 months have been negative. Subject should have undergone at least 2 cultures within the past 12 months, with a minimum interval of 3 months between each culture, and at least one culture should have been conducted within 6 months prior to screening in this study. 3. During screening, the 12 lead electrocardiogram showed prolonged QTcF interval (\>450 ms for males and\>460 ms for females) and clinically significant abnormalities in other indicators of the 12 lead electrocardiogram. 4. During screening, total bilirubin exceeded the upper limit of normal, ALT and AST exceeded three times the upper limit of normal, and blood creatinine (CRE) was ≥ 1.5 times the upper limit of normal. 5. History of physical organ or blood transplantation or registered waiting for transplantation; 6. During screening, positive for human immunodeficiency virus antibodies (HIV Ab) and positive for Treponema pallidum specific antibodies (TPPA); 7. Participated in inhalation drug or device studies within 30 days prior to the initial screening visit (a 30 day window period applies to inhalation drugs with elimination half-life\<6 days. If the elimination half-life of inhalation drugs is ≥ 6 days, the window period should be extended to at least 5 half lives after the last administration); 8. Pregnant (positive blood pregnancy test result) or lactating women; 9. Having a history of drug allergies or other allergies, which investigators consider to be contraindications for participation in the study; 10. History of drug allergies or other allergies, and investigators believe it contraindications for participation in the study; 11. Investigators believe that any medical indicators (including other laboratory test indicators with clinical significance) or other conditions that may affect clinical trials.