Objective: To determine the effect of low-dose ketamine versus lignocaine on post-operative pain in patients undergoing LC under general anesthesia in a tertiary care hospital. Sample Selection: Patients of both the gender of age at least 18 years, planned for elective LC with ASA grade I-II were included. Patients with obesity, history of alcohol consumptions, drug abusers, uncontrolled hypertension and diabetics, with chronic pain, allergic to study drugs, having neurological disorders, unable to understand pain scoring system and converted to open LC were excluded.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
100
Ketamine group received ketamine at 0.2mg/kg bolus intravenously followed by ketamine infusion at rate of 0.2mg/kg/hr throughout the surgery.
IV Lignocaine was given at the rate of 1 mg/kg/hr.
Fazaia Ruth Pfau Medical College
Karachi, Sindh, Pakistan
Post operative Pain
Pain was assessed using Numeric Rating Scale which is a ten point scoring scale ranging from 0-10 for ranking pain where 0 means no and 10 means worst pain.
Time frame: 24 hours
Time to rescue analgesia
Time to rescue analgesia was defined as time point at which patient will be given first rescue analgesia for pain of score more 5 or above.
Time frame: 24 hours
Wound Closure
The time between the incision and the wound's closure was used to define the length of the surgery.
Time frame: End of Surgery
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