Using Neuroimaging to Early Diagnose Alzheimer's Disease Through Hippocampal Atrophy Assessment

Centre Hospitalier de Saint-Denis85 enrolled

Overview

This study aims to better understand Alzheimer's disease by looking at brain scans, specifically MRI images, to detect early signs of brain changes linked to the disease. Researchers are focusing on the hippocampus, a part of the brain that shrinks in people with Alzheimer's. The study will also explore other brain changes that often happen alongside hippocampal shrinkage. By analyzing these brain images, the study hopes to find ways to diagnose Alzheimer's earlier and more accurately using advanced imaging techniques.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Alzheimer's Disease Hippocampus Brain Atrophy Magnetic Resonance Imaging Leukoaraiosis Neurodegenerative Diseases Cortical and Subcortical Atrophy

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who underwent a brain MRI (3D T1 Bravo and Cube FLAIR sequences) between January 2018 and June 2022. * Diagnosis of Alzheimer's disease (for the Alzheimer group). * No neurological disease for control group participants. * Complete clinical and biological assessments available. * Quality imaging without motion artifacts. Exclusion Criteria: * Incomplete clinical or radiological data. * Poor image quality (e.g., motion artifacts). * Presence of other neurodegenerative or psychiatric disorders.

Outcomes

Primary Outcomes

Hippocampal Volume Measured by 3D MRI

Objective volumetric measurement of the right and left hippocampus using 3D T1 Bravo MRI sequences, allowing quantification of hippocampal atrophy.

Time frame: Retrospective analysis between January 2018 and June 2022