Transcranial Electrical Stimulation in Multiple Sclerosis

Overview

First the investigators will examine if the blood flow in the brain is different in patients with Multiple Sclerosis compared to healthy volunteers. HOW? \- The blood flow of the subjects is imaged by use of a special MRI-technique. Secondly, the investigators will examine if the blood flow can determine disease progression. HOW? - Multiple Sclerosis patients are asked for a follow-up visit after two years. The main goal is to understand the effect of transcranial Direct Current Stimulation (tDCS) on the cerebral blood flow. * Does tDCS result in a different blood flow, in which brain regions? * Is there a difference between healthy volunteers and Multiple Sclerosis patients? HOW? \- Participants get two session of tDCS. Before, during and after stimulation MRI scans are performed.

Comparison of CBF between healthy volunteers and MS patients: \- Arterial spin labelling (ASL) is used to investigate cerebral blood flow in patients with MS and healthy volunteers. The effect of transcranial direct current stimulation (tDCS) on cerebral blood flow: * ASL scans are performed before-, during-, and after tDCS * Each subject will receive active and sham tDCS (seperated by at least two days) (cross-over design). Follow-up visit: * After two years, patients with MS are re-invited. * This visit will include a new neuropsychological evaluation, blood sampling and additional brain scans.

Conditions