The main goal is to elucidate the mechanistic coupling between inflammation and the ability to maintain skeletal muscle through physical exercise while hospitalized. We will investigate protein kinetics in patients who belong to one of three groups 1) high inflammatory state, 2) moderate inflammatory state and 3) low/no inflammation. We will further intervene in group 1 (high inflammatory state) with anti-inflammatory nutrition (primarily green-solution plant-based) to diminish activity in inflammatory pathways. The hypothesis is that inflammation will inhibit protein synthesis in skeletal muscle both in resting muscle and in strength trained skeletal musculature, and that a lowering of the inflammatory status by anti-inflammatory nutrition will enhance the exercise induced formation of new muscle mass. .
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
90
All subjects will train one leg twice daily.
Bispebjerg Hospital
Copenhagen, Denmark
FSR in high vs. low inflammation group
The primary outcome is the muscle protein fractional synthesis rate (FSR) in the high inflammation group vs. the low inflammation group
Time frame: 7 days (or until hospital discharge)
Change in muscle size between groups
Change in muscle size during the study period between the three groups
Time frame: 7 days (or until hospital discharge)
FSR in trained vs. non trained leg
Effect of training on the muscle protein fractional synthesis rate
Time frame: 7 days (or until hospital discharge)
Inflammation in regular vs. antiinflammatory diet
Comparison of the changes in plasma C-Reactive Protein (CRP) from day 1 till discharge between the group ingesting regular diet vs. the group ingesting an anti-inflammatory diet.
Time frame: 7 days (or until hospital discharge)
AA uptake following feeding
Plasma amino acid profile following a standard meal
Time frame: 7 days (or until hospital discharge)
Muscle size in trained vs. untrained leg
The difference in muscle size in trained vs. untrained leg measured using ultrasound
Time frame: 7 days (or until hospital discharge)
Change in muscle strength between groups
Description: Change in muscle strength during the study period between the three groups. Hand muscle strength is measured using a hand dynamometer, and leg muscle strength (MVC) is measured using an isokinetic dynamometer. Time Frame: 7 days (or until hospital discharge)
Time frame: 7 days (or until discharge)
Muscle strength in trained vs. untrained leg
The difference in leg muscle strength (MVC) in trained vs. untrained leg measured using an isokinetic dynamometer.
Time frame: 7 days (or until hospital discharge)
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