Prone Positioning in ARDS: Predicting Neurological Complications via Cerebral Hemodynamics
Collecting Medical Records, Demographic Characteristics, and Clinical Data of Moderate to Severe ARDS Patients Requiring Prone Positioning Treatment at Chengdu Pixdu District People's Hospital, Sichuan Provincial People's Hospital, The Fourth People's Hospital of Chengdu, and Chengdu Shuangliu District First People's Hospital from March 2025 to March 2026.
Study Type
OBSERVATIONAL
Enrollment
50
Cerebral Blood Flow Monitoring Before and After Prone Ventilation in Patients with ARDS.Cerebral blood flow,intracranial pressure,and systemic hemodynamic monitoring were performed at the following time points:before prone positioning(T0),1 hour after prone ventilation(T1),12 hours after prone ventilation(T2),1 hour after returning to the supine position(T3),and 7 days after returning to the supine position(T4).
Sichuan Provincial People's Hospital,
Chengdu, Sichuan, China
RECRUITINGNeuroimaging Studies
Cranial CT or MRI Scans Conducted Before and After Prone Positioning to Detect New-Onset Neurological Complications Such as Cerebral Edema, Intracranial Hemorrhage, and Cerebral Infarction
Time frame: From enrollment to 2 weeks after the end of treatment.
Biomarker Detection
Blood samples were collected for NSE(Neuron-specific Enolase)and IL-6(Interleukin-6)before and after prone positioning.
Time frame: From enrollment to 2 weeks after the end of treatment.
Incidence rate of delirium
Assessment using the Confusion Assessment Method for the Intensive Care Unit(CAM-ICU)was conducted before and after prone position therapy in patients.
Time frame: From enrollment to 2 weeks after the end of treatment.
Cognitive function
Assessment using the Mini-Mental State Examination(MMSE)was conducted before and after prone position therapy in patients.
Time frame: From enrollment to 2 weeks after the end of treatment.
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