The Relationship Between Delirium and BDNF in Coronary Artery Bypass Graft Surgery

Pomeranian Medical University Szczecin107 enrolled

Overview

This study is aimed at finding a correlation between postoperative delirium occurrence, severity and duration after cardiac surgery and the level of brain-derived neurotrophic factor (BDNF) in plasma as a marker of brain injury induced by cardio-pulmonary by-pass and its association with genetic predisposition in patients undergoing coronary artery bypass grafting (CABG) carrying BDNF gene polymorphism (Val66Met).

Study Type

OBSERVATIONAL

Enrollment

107

Conditions

Delirium - Postoperative BDNF CABG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion criteria include: 1. Age \> 18 years. 2. Planned coronary artery bypass grafting (CABG) procedure with the use of cardiopulmonary by-pass (CPB). 3. Ability to understand and sign an informed consent form. Exclusion criteria include: 1. Emergency surgery. 2. Previous known cognitive disorders: Mini Mental State Examination (MMSE) score \<15. 3. Baseline delirium (positive CAM test prior to surgery). 4. Diagnosis of psychiatric syndromes in the past - i.e. depression, dementia, psychosis or schizophrenia. 5. Inability to understand Polish language. 6. Inability to give and sign informed consent due to auditory or visual dysfunction.

Locations (1)

Uniwersytecki Szpital Kliniczny nr 2 PUM w Szczecinie

Szczecin, West Pomeranian Voivodeship, Poland

Outcomes

Primary Outcomes

The main aim of the study will be to assess the correlation between brain function disorders, defined as abnormal BDNF levels, and postoperative delirium.

Time frame: Up to a year after the procedure.

Data from ClinicalTrials.gov

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