Analysis of Early Neurodevelopmental Alterations in Bipolar Disorder Based on Cortical Organoid Models

Inclusion Criteria: * Presence of bipolar disorder according to DSM-5 criteria * Able to freely give and sign consent * Affiliated or beneficiary of a health insurance plan * Previous participants in the NEMO study (2022-A00353-40) For the "neurodevelopmental bipolar" (ND-BP) group: presence of a neurodevelopmental burden score in the top 5, as assessed in the NEMO project (NCT05674019). For the "non-neurodevelopmental bipolar" group (TB): presence of a neurodevelopmental load score of 0, or in the lowest 5, as assessed in the NEMO project. Exclusion Criteria: * \- Presence of a severe symptomatic or unstable physiological or medical condition (including pregnancy) * History of psychiatric illness (stable or not), schizophrenia or any other pathology likely to interfere with bipolar disorder * History of severe head trauma (GCS\<8 at time of trauma) * Presence of a neurological disorder affecting central nervous system function * Presence of moderate to severe substance use disorders (\>=4/11 as defined in DSM-5), with the exception of tobacco use disorders. * The volunteer is under court protection or guardianship * It proves impossible to give the volunteer informed information, or the volunteer refuses to sign the consent form. * Insufficient command of the French language to complete evaluations