Hydrogen-Rich Water and Metabolic Health in Adults: A 12-Week Randomized Trial

University of Novi Sad, Faculty of Sport and Physical Education40 enrolled

Overview

The HYDRO-RESPOND trial is a 12-week randomized controlled study investigating the effects of daily hydrogen-rich water (HRW) consumption on body composition and metabolic biomarkers in adults diagnosed with metabolic syndrome. The study also explores whether individual differences in baseline breath hydrogen levels influence response to HRW. Participants are randomly assigned to receive either HRW or a placebo, with outcomes including changes in body fat, waist circumference, glucose metabolism, lipid profiles, and inflammatory markers. The trial aims to determine the therapeutic potential of HRW and identify predictors of individual responsiveness.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

Conditions

Metabolic Syndrome

Interventions

Eligibility

Sex: ALLMin age: 30 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 30-65 years * Metabolic syndrome (NHS) (at least 3 of the 5 following criteria): * Waist circumference of ≥ 102 cm in men and ≥ 88 cm in women * Hypertriglyceridemia (≥ 1.695 mmol/L) * Low HDL-C (\< 1.04 mmol/dL in men and \< 1.30 mmol/dL in women) * High blood pressure (\> 130/85 mmHg) * High fasting glucose (\> 6.1 mmol/L) * Not physically active * Informed consent signed Exclusion Criteria: * Major chronic disease and acute injuries * History of dietary supplement use during the past 4 weeks * History of metabolism-modulating pharmaceuticals use during the past 4 weeks * No consent to randomization * Participation in other studies

Outcomes

Primary Outcomes

Waist circumference

Waist circumference, measured at the midpoint between the lower rib and iliac crest, serves as an indicator of abdominal adiposity and a key outcome reflecting metabolic risk.

Time frame: Change from baseline waist circumference at 12 weeks

Secondary Outcomes

Body fat

Body fat measured with bioimpedance analysis

Time frame: Change from baseline body fat at 12 weeks

Lipoprotein (a)

Serum levels of lipoprotein (a)

Time frame: Change from baseline lipoprotein (a) at 12 weeks

Total antioxidant capacity

Serum levels of total antioxidant capacity

Time frame: Change from baseline total antioxidant capacity at 12 weeks