The purpose of this study was to evaluate the efficacy of 1 capsules of ABKefir per day on symptoms of constipation in subjects with functional constipation by clinical trial.
This randomized, placebo-controlled clinical trial will be conduct for 8 weeks with one hundred and sixty-five adults. Subjects will be recruited and randomly assigned into three groups: (1) placebo, n = 55; (2) low dose of ABKefir , n = 55; (3) high dose of ABKefir, n = 55. During the first 4 weeks of supplement, the subjects should take one capsule of placebo or ABKefir daily. Apart from containing no probiotics, the content of placebo is same as ABKefir. After that, the next 4 weeks is to have a follow-up of subjects. During this phase, subjects don't need to supplement. Subjects should complete the assessment of anthropometric measurement, defecation questionnaire , food record, feces and blood collection at week 0, 4 and week 8.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
165
Take a capsule of placebo within 30 minutes after breakfast, and once a day.
Take a capsule of ABKefir within 30 minutes after breakfast, and once a day.
Chung Shan Medical University
Taichung, South, Taiwan
RECRUITINGChange from baseline symptoms of constipation at week 4 and 8
Compared the difference of bowel movements between the week 0, 4 and 8.
Time frame: Week 0, 4 and 8
Change from baseline symptoms of constipation at week 4 and 8
Compared the difference of stool consistency between the week 0, 4 and 8.
Time frame: Week 0, 4 and 8
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