Endometriosis is a chronic inflammatory disease affecting \~10% of women of childbearing age. It is characterized by the presence of endometrial-like tissue outside the uterus, causing lesions and adhesions between the organs, and is often accompanied by intense pain and sometimes infertility. The four-stage classification based on the severity of lesions does not always reflect the severity of symptoms. Adenomyosis, a similar pathology, is often present in the same patients, although it is now considered distinct from endometriosis. Diagnosis usually takes a long time, with an average delay of 7 years. The cause of the disease remains unknown, but hormonal, genetic and environmental factors, such as exposure to endocrine disruptors, are suspected. Persistent organic pollutants (POPs), such as dioxins and PCBs, may influence the risk and severity of the disease. Although experimental studies suggest a link between these substances and the progression of endometriosis, epidemiological research on the subject is still limited. The central hypothesis of the POPENDO project is that higher concentrations of persistent organic pollutants (POPs) are associated with increased severity of endometriosis. The aim of the study is to explore the associations between serum levels of four families of POPs (PCBs, organochlorine pesticides, PFAS and BFR) and endometriosis.
Study Type
OBSERVATIONAL
Enrollment
650
24mL blood sample (3 dry tubes with 8mL)
Hôpital Paris Saint Joseph
Paris, France
Assessment of the severity of endometriosis, defined by the type of disease.
Analysis of several online questionnaires on endometriosis by participants
Time frame: During 3 last years of analysis
Evaluation of serum levels of polychlorinated biphenyls (PCBs)
Chemical analysis of participants' blood samples by the LABERCA laboratory
Time frame: 5 months after inclusion start until analysis of the last participant' blood sample
Evaluation of serum levels of per- and polyfluoroalkylates (PFAS)
Chemical analysis of participants' blood samples by the LABERCA laboratory
Time frame: 5 months after inclusion start until analysis of the last participant' blood sample
Evaluation of serum levels of Brominated flame retardants polluent (BFRs)
Chemical analysis of participants' blood samples by the LABERCA laboratory
Time frame: 5 months after inclusion start until analysis of the last participant' blood sample
Evaluation of serum levels of organochlorine pesticides (POCs)
Chemical analysis of participants' blood samples by the LABERCA laboratory
Time frame: 5 months after inclusion start until analysis of the last participant' blood sample
definition of the level of severity of endometriosis by the rASRM stage (revised stage of the American Society for Reproductive Medicine)
Analysis of online questionnaires on endometriosis and rASRM stage
Time frame: During 3 last years of analysis
definition of the level of severity of endometriosis by the anatomical extension of the disease observed on MRI
Pelvic MRI images will be reviewed by radiologists from Hôpital Paris Saint Joseph to map endometriosis across 21 anatomical structures within 5 pelvic segments, using the ENZIAN classification to assess lesion location and severity.
Time frame: During 3 last years of analysis
endometriosis severity level defined by the severity of painful symptoms.
Analysis of annual follow-up questionnaire of ComPaRe-Endometriosis study participant assessing the severity of various pain types over the past three months using a numeric rating scale.
Time frame: During 3 last years of analysis
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