The investigator proposes to examine the effects of excitatory transcranial magnetic stimulation (TMS) combined with semantic feature analysis (SFA) language therapy to improve word-finding abilities in stroke survivors with aphasia (SWA).
In this project, the investigator will use functional neuroimaging and inhibitory TMS to determine precise therapy-responsive targets for excitatory TMS therapy with SFA. One group of stroke survivors will receive SFA + TMS targeting the precision site, and another group will receive SFA + TMS targeting a control site. The primary outcome will be changes in picture naming accuracy. We expect that excitatory TMS targeting a precision site would result in larger improvements in naming accuracy than TMS targeting a control site. Results will provide the efficacy of precision TMS in post-stroke aphasia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
50
Excitatory TMS delivered using a precision site finding approach and intermittent theta burst stimulation protocol
Excitatory TMS using intermittent theta burst stimulation delivered to a control vertex site.
Medical College of Wisconsin
Milwaukee, Wisconsin, United States
RECRUITINGAccuracy on a picture naming test
Changes in accuracy on untrained stimuli after SFA+TMS compared between groups (precision, control).
Time frame: immediately after and 8-12 weeks after last SFA+TMS treatment
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