Understanding the pathogenesis of eye diseases has benefited greatly from recent advances in ophthalmic imaging. However, current clinical imaging systems, such as optical coherence tomography (OCT), are limited in terms of resolution, acquisition speed or access to certain eye functions. Our team has participated in the development of a new generation of imaging technology known as optical transmission tomography (OTT), which enables imaging of the anterior parts of the eye with high cellular resolution, a wide field of view and reduced examination delay.
For healthy subjects: an imaging examination using each system (OTT + OCT + specular microscopy) will be carried out twice, at an interval of two (2) years (inclusion visit + visit at 24 months). Several imaging images will be taken by two different operators during these sessions. For patients: an imaging examination using each system (OTT + OCT + specular microscopy) will be carried out by two different operators, and several imaging images will be taken. These examinations will be carried out at the inclusion visit and at the following visits according to the disease assessment schedule, lasting up to a maximum of 4 years.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
300
Multiple imaging sessions added by research using the systems described (OTT) will be carried out by two different operators at different positions during these sessions.
Multiple imaging sessions (OCT) already used in standard of care will be performed by two different operators at different positions during these sessions.
Multiple imaging sessions (SM) already used in standard of care will be performed by two different operators at different positions during these sessions.
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Paris, France
RECRUITINGImage quality
Quality assessed by two blinded experts. This is an evaluation of image quality in terms of operation according to the following scheme. Quality assessment: \- Sufficient quality : Yes Or No If no, tick yes, below and fill in the cause: Insufficient quality: ☒ yes ☐ no Cause: * Technical problem Or * Patient-related problem (inability to fix, or comply with procedure, etc.)
Time frame: between 1 day and 4 years
Endothelial cell density
Assessment of endothelial cell density.
Time frame: between 1 day and 4 years
Imaging new corneal and lens structures
corneal and lens structures:measure density in other cell types
Time frame: between 1 day and 4 years
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