Effect of Intradialytic Blood Flow Restriction Training on Functional Capacity, Estimated Glomerular Filtration Rate and Health Related Quality of Life in Patients on Hemodialysis

Beni-Suef University30 enrolled

Overview

this study was done to investigate the effect of intradialytic blood flow restriction training on functional capacity, estimated glomerular filtration rate and health related Quality of life in patients on Hemodialysis

Chronic kidney disease affects 10% to 15% of the population and is characterized by a progressive decline in glomerular filtration rate. The disease can lead to frailty, muscle mass wasting, and sarcopenia, affecting functional mobility and quality-of-life measures. The increased protein catabolism in Chronic kidney disease is partly due to inflammatory status, nutrient loss during dialysis, and musculoskeletal system changes. Assessment of muscle functionality can provide additional diagnostic and prognostic information for clinical outcomes, quality of life, and mortality rates. Exercise training with blood flow restriction is a potential method for clinical musculoskeletal rehabilitation, potentially improving strength, physical function, blood pressure control, glucose homeostasis, autonomic function, renal deterioration, dialysis adequacy, and antioxidant defenses.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Blood Flow Restriction Training Glomerular Filtration Rate Quality of Life Hemodialysis

Interventions

conventional exercise ProgramOTHER

Exercises include shoulder flexion, shoulder abduction, leg extension, and hand grip. Start with 1-3 sets of 12 reps at 30% of 1-repetition maximum, increasing by 10% according to patient endurance. Cycling is a 30-minute chair or bedside cycle ergometer exercise 2 time/weak for 2 consecutive months

blood flow restriction trainingOTHER

Patients received the same conventional exercise program, which included isometric, aerobic, and resisted exercise individualized for every patient with blood flow restriction by 50% of limb occlusion pressure. Training will be conducted for 2 time/weak for 2 consecutive month

Eligibility

Sex: ALLMin age: 40 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: All patients were 1. Both sex aged from forty to sixty years 2. Stable chronic hemodialysis patient (\< 3 months) 3. Participants will be deemed medically eligible by their treating physician before participation in the present study 4. Free from any other disease could interfere with exercise Exclusion Criteria: 1. Hemodynamic instability during hemodialysis over the last month 2. Neurodegenerative diseases 3. Autoimmune diseases (i.e., lupus erythematosus) 4. Surgery within the past 3 months 5. Severe arrhythmia, angina or cerebrovascular disease 6. Unstable on dialysis 7. Any musculoskeletal problem interfere with exercise

Locations (1)

out-patient clinic, faculty of physical therapy, beni-suef University

Banī Suwayf, Egypt

Outcomes

Primary Outcomes

assessment of change of estimated glomerular filtration rate

Estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration Creatinine Equation (2021) as recommended by the National Kidney Foundation to assess renal function and detect deterioration.