This study aimed to compare the effectiveness of intraoperative magnesium sulfate versus dexmedetomidine infusions on emergence agitation that follows anesthesia using sevoflurane immediately and after 30 min in the post-anesthesia care unit (PACU), regarding Pediatric Anesthesia Emergence Delirium Scale (PAED), Richmond agitation sedation scale (RASS), and hemodynamics
Emergence agitation (EA) is a postoperative phenomenon that occurs in children after sevoflurane anesthesia, with an occurrence rate of up to 80%. Dexmedetomidine acts on α-2 adrenergic receptors, producing sedation and hypnosis with anxiolytic effects, without a clinically significant depressive impact on heart rate, blood pressure, and respiratory rate, complementing an earlier study suggesting the possible effective and safe use of dexmedetomidine as a part of anesthesia care to prevent emergence agitation in children. Magnesium sulfate also has been reported to decrease the incidence and severity of Emergence agitation and the need for postoperative rescue doses of analgesia in children, and its use was not associated with increased postoperative side effects or delayed recovery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
60
Patients received an initial intravenous loading dose of 30 mg/kg of 10% magnesium sulfate solution over 10 min. This will be followed by a continuous infusion of (10mg/kg/hr) for the entire duration of surgery.
Patients received dexmedetomidine infusion 0.5 μg/kg over 10 min as a bolus dose, followed by 0.2 μg/kg/h all over the operation.
Ain shams university
Cairo, Egypt
Pediatric Anesthesia Emergence Delirium Scale
Pediatric Anesthesia Emergence Delirium Scale (PAED). The PAED Scale consists of five characteristics that are each scored by using a 5-point Likert scale: * The child makes eye contact with the caregiver * The child is aware of his or her surroundings * The child's actions are purposeful, * The child is restless * The child is inconsolable We set the threshold score for the presence of pediatric emergence delirium using the PAED Scale at a score higher than or equal to 10 based on the sensitivity and specificity reported in the literature.
Time frame: 30 minutes postoperatively
Richmond agitation sedation scale (RASS)
The Richmond agitation sedation scale (RASS) assesses five levels of sedation: * (5) unarousable with no response to voice or physical stimulation * (4) deep sedation with no response to voice but movement to physical stimuli * (3) moderate sedation with movement to voice but no eye contact * (2) light sedation and briefly awakens (ie, less than 10 seconds) with eye contact to voice * (1) drowsy (ie, not fully alert) but has sustained (ie, more than 10 seconds) awakening with eye contact to voice
Time frame: 30 minutes postoperatively
Heart rate
Heart rate will be recorded from the start of injection till 30 minutes postoperatively.
Time frame: 30 minutes postoperatively
Blood pressure
Blood pressure will be recorded from the start of injection till 30 minutes postoperatively.
Time frame: 30 minutes postoperatively
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