Cesarean section often leads to postoperative scarring, which can impact both physical and psychological well-being. Platelet-rich plasma (PRP), rich in growth factors, is used in regenerative medicine to promote healing and reduce inflammation.
Background: Cesarean section often leads to postoperative scarring, which can impact both physical and psychological well-being. Platelet-rich plasma (PRP), rich in growth factors, is used in regenerative medicine to promote healing and reduce inflammation. Objective: To evaluate the efficacy of intraoperative PRP in accelerating scar healing after cesarean section, using: Six visual scar assessment scales (Manchester, POSAS, Vancouver, VAS, NRS, REEDA) Hematological parameters (hemoglobin, hematocrit, leukocytes, platelets) Methods: Design: Prospective clinical study, 100 patients undergoing cesarean section with intraoperative PRP. Intervention: 10 ml PRP administered intraoperatively (5 ml before hysterography, 5 ml subcutaneously before skin closure). Assessments: Scar evaluation at day 7 and day 40 post-op using six scar scales; hematological parameters measured at both time points. Statistics: Wilcoxon paired samples test and Pearson correlation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
100
Patients receive platelet-rich plasma (PRP) intraoperatively during cesarean section (5 ml before hysterography, 5 ml subcutaneously before skin closure).
Saint Andrew Hospital
Constanța, Constanța County, Romania
Patient and Observer Scar Assessment Scale (POSAS)
The Patient and Observer Scar Assessment Scale (POSAS) POSAS Score Overview: Scale range: Each item is scored from 1 to 10 Minimum total score: 6 (best possible scar) Maximum total score: 60 (worst possible scar) Higher scores indicate worse scar quality Lower scores indicate better scar quality (closer to normal skin)
Time frame: up to 40 days
Visual Analog Scale (VAS)
0 = "No pain" 10 = "Worst imaginable pain" Scoring: The patient marks a point on the line corresponding to their perceived symptom intensity. 0 = no pain/symptom 10 = worst possible pain/symptom Higher scores = worse symptoms
Time frame: up to 40 days
Redness, Erythema, Edema, Ecchymosis, Discharge
Change in REEDA score (Erythema, Edema, Ecchymosis, Discharge, Approximation) as an indicator of inflammation and healing. Total Score Range: Minimum: 0 → Excellent healing Maximum: 15 → Poor healing / possible infection 0-4: Normal or mild changes; generally satisfactory healing 5-7: Moderate impairment; monitor healing 8-15: Significant impairment; possible infection or dehiscence; needs medical attention
Time frame: up to 40 days
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