Construction of Clinical Diagnostic Model for Pulmonary Hypertension

Overview

Primary objective: To establish a non-invasive diagnostic model for pulmonary hypertension based on laboratory indicators and echocardiographic parameters. Secondary objectives: To investigate the correlations between laboratory test indicators and echocardiographic data, and to develop new parameters based on preliminary analysis to assist in the diagnosis of pulmonary hypertension

Data collection: Collect vital signs (age, sex, etc.), clinical laboratory tests (complete blood count, biochemistry, BNP, D-dimer, and related derived parameters), and echocardiographic data from both the control group and pulmonary hypertension (PH) patients. Obtain hemodynamic data measured via right heart catheterization (RHC) in PH patients. Model development: Construct a clinical diagnostic model using laboratory and echocardiographic data. Fit hemodynamic parameters of PH patients based on their laboratory indicators, then assess the hemodynamic status using the fitted parameters and compare with actual measurements. Secondary analyses: Investigate correlations between echocardiographic parameters and laboratory test indicators in PH patients. Identify core variables to develop novel diagnostic parameters and evaluate their diagnostic performance.

Conditions

Eligibility

Locations (1)

Outcomes