The aim of this prospective randomized controlled double-blinded study is to compare the efficacy of dexmedetomidine, MgSO4 and lidocaine for cough suppression during general anesthetic emergence as regard number and severity.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
300
Patients will receive 0.5 μg/kg dexmedetomidine in 10ml normal saline 10 min before the end of surgery.
Patients will receive 30 mg/kg IV magnesium sulfate 50% 10 min before the end of surgery.
Patients will receive lidocaine 1.5 mg/kg lidocaine 10 min before the end of surgery.
Faculty of Medicine, Al-Azhar university Assiut, Egypt.
Asyut, Egypt
RECRUITINGCough suppression as regard number and severity.
Coughing severity will be classified using the 3 point scale described by Minogue et al.: 1 = mild, single cough, 2 = moderate (lasting for \<5 seconds) cough, and severe (lasting for \>5 seconds) cough.
Time frame: at 0 and 10,20,30,40 minutes after endotracheal extubation.
Intraoperative heart rate (HR).
Changes in Intraoperative heart rate. change in heart rate per minute (HR/minute) will be all measured from the patient's arrival at the operating room to the end of surgery.
Time frame: at 15-minutes interval.
Intraoperative mean arterial blood pressure (MAP).
Changes in Intraoperative mean arterial blood pressure (MAP). change in mean arterial blood pressure (MAP) in mmHg will be all measured from the patient's arrival at the operating room to the end of surgery.
Time frame: at 15-minutes interval.
Intraoperative arterial oxygen saturation (Spo2).
Changes in Intraoperative arterial oxygen saturation (Spo2%). change in arterial oxygen saturation (Spo2%). be all measured from the patient's arrival at the operating room to the end of surgery.
Time frame: at 15-minutes interval.
Sedation score.
Sedation score will be recorded using the Ramsay sedation score (Ramsay et al., 1974).
Time frame: at 0,10,20,30, and 40 minutes after tracheal extubation.
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Patients will receive 10 ml normal saline 10 min before the end of surgery.