Glycemic Control Following Occupational Work in a Hot Environment

N/ANot Yet RecruitingNCT06982612

Loughborough University20 enrolled

Overview

Occupational workers regularly perform physically demanding tasks in hot environments, exposing them to heat stress and potential dehydration. While the physiological impacts of heat exposure are well-documented, its effects on glycemic control remain less understood. Given the rising global temperatures due to climate change and the increasing prevalence of metabolic disorders such as obesity and type 2 diabetes, it is essential to investigate how heat exposure during work influences glycemic regulation. Understanding these interactions will help inform future occupational health guidelines and metabolic health recommendations in physically demanding industries.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Plasma Glucose Following Prolonged Heat Exposure

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male or female * Generally fit and healthy * Participate in endurance or intermittent exercise at least 3 times a week or minimum of 150 minutes moderate intensity activity per week Exclusion Criteria: * Under 18 or 45 and over, * any morbidity or medication that might influence carbohydrate/fat metabolism (i.e., liver/renal/cardiovascular disease) or cycling ability (musculoskeletal injury etc), * coagulation or bleeding disorders, * blood-borne illness, * heart conditions, * congenital heart disease, * uncontrolled exercise-induced asthma, * smoking (including vaping), * allergies to the products used in the study, * dieting or restrained eating behaviours. * Females with amenorrhea would be an exclusion criteria.

Outcomes

Primary Outcomes

Plasma glucose

Measured using colorimetric assay from venous blood samples

Time frame: 8hours

Secondary Outcomes

Plasma insulin

Measured using ELISA from venous blood samples

Time frame: 8hours

Plasma osmolality

Measured using freezing point depression from venous blood samples

Time frame: 8hours

Plasma volume change

Determined from haemoglobin and haematocrit measures in blood samples

Time frame: 8hours

Urine volume

Determined from urine samples collected before and after exercise

Time frame: 8hours

Body mass

Determined from weighing participants before and after exercise

Time frame: 8hours

Urine specific gravity/osmolality

Determined from urine samples collected before and after exercise

Time frame: 8hours

Rectal temperature

Measured via rectal probe

Time frame: 8hours

Blood pressure

Measured via and automated sphygmomanometer

Time frame: 8hours

Respiratory gas exchanges

Measured via Douglas bag, gas content and volume

Time frame: 8hours

Rate of perceived exertion

using Borg scales (from 6 \[no effort\] to 20 \[maximal effort\])

Time frame: 8hours

Rate of thermal sensation

using -10 \[cold\] to +10 \[hot\] scale.

Time frame: 8hours

Feelings of thirst, urge to urinate, GI comfort, and stomach bloatedness

using scales (0 = no feeling, 10 = extreme feeling)

Time frame: 8hours

Glycemic Control Following Occupational Work in a Hot Environment

Overview

Conditions

Interventions

Eligibility

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts