Searching electrical activity registered by EEG in acute ischemic and hemorrhagic stroke and comparing these parameters to the poststroke recovery patterns to investigate the role of EEG as a differentiation tool and as a predictor of post-stroke recovery.
In this study, EEG will be performed on each patient included; within 72 hours of the onset of the stroke. The EEG device will be used within the intended use as described in the user manuals. The electrodes are put on the patient's head, and the EEG signal is recorded for several minutes; the amplifier is used to amplify the EEG signal and reduce artifacts. A complete EEG and data will be collected at baseline and on follow-up to observe the differences in EEG patterns to perform a qualitative assessment of the EEG results. EEG patterns depend on the size and location of acute ischemic stroke, including generalized or focal slowing or both and epileptiform discharges. Abnormal neuronal activity is determined by comparing a part of the patient's brain not affected by stroke to a part of the patient's brain affected by stroke. Moreover, Abnormal blood flow is interpreted by comparing the abnormal EEG patterns in the areas of infarctions or hemorrhage to the normal brain tissue signals. The aim is to compare electric waveforms from an EEG device between patients with acute ischemic and acute hemorrhagic stroke (at baseline which is within 72 hours of the onset of acute ischemic and acute hemorrhagic stroke and through study completion, an average of 3 to 6 months).
Study Type
OBSERVATIONAL
Enrollment
300
Neurology Department, Faculty of Medicine, Assiut University
Asyut, Asyut Governorate, Egypt
RECRUITINGProportion of Participants With Focal Slowing in the Stroke-Affected Hemisphere
Presence of focal slowing (e.g., increased delta or theta activity) in the stroke-affected hemisphere versus the unaffected hemisphere. Patterns categorized as "ischemic" or "hemorrhagic."; this will be measured in percentage (%).
Time frame: Baseline (within 72 hours of stroke onset)
Proportion of Participants With Interhemispheric Asymmetry in EEG Waveforms
Qualitative assessment of EEG asymmetry between affected and unaffected hemispheres at baseline. Frequency of each will be measured in percentage (%).
Time frame: Baseline (within 72 hours of stroke onset)
Proportion of Participants With Absent or Diminished EEG Reactivity
Absence or reduction in EEG reactivity to external stimuli (e.g., auditory, tactile) in the affected hemisphere; this will be measures by precentage (%).
Time frame: Baseline (within 72 hours of stroke onset)
Proportion of Participants With Epileptiform Activity on EEG
Presence of epileptiform discharges (e.g., spikes or sharp waves) on EEG in the stroke-affected hemisphere; thsi will be measured by precentage (%).
Time frame: Baseline (within 72 hours of stroke onset)
Correlation Between Baseline EEG Findings and Functional Recovery
Association between initial qualitative EEG abnormalities (e.g., focal slowing, asymmetry) and functional outcomes measured by standardized scales (e.g., Modified Rankin Scale) at 6 months; measured by Correlation coefficient (r).
Time frame: Phase I (Baseline EEG assessment) and Phase III (3 to 6 month follow-up functional evaluation)
Prediction of Post-Stroke Seizures Based on EEG Findings
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Proportion of participants with specific EEG abnormalities (e.g., epileptiform activity) at baseline who develop post-stroke seizures within 3 to 6 months, measured by percentage (%).
Time frame: Phase I (Baseline EEG assessment) and Phase III (3 to 6 month follow-up functional evaluation)