The goal of this clinical trial is to evaluate the immunogenicity of simultaneous administration of varicella live attenuated vaccine (varicella vaccine hereafter) and trivalent inactivated influenza vaccine (TIV hereafter). It will also evaluate the safety of simultaneous administration of the two vaccines. The main questions it aims to answer are: * If geometric mean titer (GMT) of varicella zoster vrius (VZV) antibody in the simultaneous administration group is non-inferior to that in the varicella vaccine separate group. * If GMT of hemagglutination inhibition (HI hereafter) antibody in the simultaneous administration group is non-inferior to that in the TIV separate group. Participants in the simultaneous administration group received a single dose of varicella vaccine and TIV simultaneously on day 0. Participants in the separate groups received a single dose of varicella vaccine or TIV on day 0, respectively.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
899
* Varicella vaccine: lyophilized powder, subcutaneous injection * TIV: Inactived, split virion, containing H1N1, H3N2 and BV strains.
lyophilized powder, subcutaneous
Inactived, split virion, containing H1N1, H3N2 and BV strains.
Jiangsu Provincial Center for Disease control and Prevention
Nanjing, Jiangsu, China
GMT of VZV antibody
GMT of VZV antibody on Day 30 after the vaccination.
Time frame: Day 30 after the vaccination
GMT of HI antibody
GMT of HI antibody on Day 30 after vaccination.
Time frame: Day 30 after vaccination
Geometric mean increase (GMI) of VZV antibody
GMI of VZV antibody on Day 30 after the vaccination.
Time frame: Day 30 after the vaccination
Seroconversion rate of VZV antibody
Seroconversion rate of VZV antibody on Day 30 after the vaccination.
Time frame: Day 30 after the vaccination
Seropositive rate of VZV antibody
Seropositive rate of VZV antibody on Day 30 after the vaccination.
Time frame: Day 30 after the vaccination
GMI of HI antibody
GMI of HI antibody on Day 30 after the vaccination.
Time frame: Day 30 after the vaccination
Seroconversion rate of HI antibody
Seroconversion rate of HI antibody on Day 30 after the vaccination.
Time frame: Day 30 after the vaccination
Seroprotection rate of HI antibody
Seroprotection rate of HI antibody on Day 30 after the vaccination.
Time frame: Day 30 after the vaccination
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