FETAL PULMONARY VEIN AND UMBILICAL ARTERY PULSATILITY INDICES AS PREDICTORS OF FETAL GROWTH RESTRICTION IN DIABETIC AND HYPERTENSIVE PREGNANT WOMEN

Cairo University82 enrolled

Overview

Diabetic and hypertensive pregnant women attending at Kasr Alani for antenatal care were subjected to Complete History taking. All the participants were scanned using B mode sonography to determine the fetal biometric parameters (BPD, HC, AC and FL).Only umbilical artery pulsatility index (UAPI) and pulmonary vein pulsatility index (PVPI) were measured in the study. UAPI and PVPI were measured between 28 and 34 weeks of gestation at the first routine ultrasound scheduled. The umbilical artery Doppler examinations were conducted on a free-floating loop at the middle of the cord, away from its placenta and fetal abdominal insertion sites. The Doppler angle was \<60°, for an optimal Doppler signal. The recording was done when fetal breathing movement or uterine contraction was absent. The Doppler wall filter was set at 50 - 100Hz, spectral peak average intensities were below 100 m/wcm2, and pulsed Doppler sample gate size was 2 mm (Adedo et al., 2022). The following umbilical artery Doppler indices (UADI) were calculated automatically by the machine: Peak Systolic Velocity (PSV) in cm/s, End Diastolic Velocity (EDV) in cm/s, Pulsatility Index (PI), Resistive Index (RI), and Systolic/Diastolic Ratio (S/D Ratio). The umbilical artery waveform pattern was also analyzed and classified into: normal diastolic flow, reduced diastolic flow, absent diastolic flow and reversed diastolic flow. The values of UAPI considered abnormal if \>95th percentile are as follows: at 28th Wk. \> 1.35, 29th Wk. \>1.32, 30th Wk. \>1.29, 31stWk \>1.27, 32ndWk. \>1.25, 33thWk \>1.22 and 34th Wk \>1.2 (Adedo et al., 2022).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Intrauterine Growth Restriction

Interventions

UltrasoundDIAGNOSTIC_TEST

All the participants were scanned using B mode sonography to determine the fetal biometric parameters (BPD, HC, AC and FL). The machine automatically calculated the estimated fetal weight using the Headlock formula. umbilical artery pulsatility index (UAPI) and pulmonary vein pulsatility index (PVPI) were measured in the study

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 44 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Pregnant women between 18 and 44 years. * Gestational age: 28 - 34 weeks of gestation at time of examination (only women with confirmed GA by sure LMP and/or first trimester US scan). * Singleton pregnancy. * Hypertensive women (preexisting or gestational hypertension). * Diabetic women (preexisting or gestational diabetes). Exclusion Criteria: * Women with any medical disorder (apart from diabetes and hypertension). * Women with multiple pregnancies. * Women with inadequate ultrasound images (i.e., marked obesity). * Women with fetuses with chromosomal abnormalities or congenital anomalies and other factors that could affect fetal growth. * Unavailable perinatal outcome data

Locations (1)

Kasr Alainy medical school

Cairo, Egypt

Outcomes

Primary Outcomes

Prediction of fetal growth restriction

Time frame: At time of delivery

Data from ClinicalTrials.gov

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