The study goal is to determine whether oral administration of a probiotic mixture can reduce the incidence of antibiotic-associated diarrhea in patients with community-acquired pneumonia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
100
Occurrence of antibiotic-associated diarrhea
Antibiotic-Associated Diarrhea (Definition: Occurrence of diarrhea more than 3 times a day, occurring at least 24 hours after the first administration of antibiotics) \* Diarrhea is defined using the Bristol Stool Form Scale (BSF) as BSF 6 or 7. BSF 6: Mushy stool \[Soft pieces with ragged edges, mushy stool\] BSF 7: Watery stool \[Liquid-like, no solid form, completely liquid\]
Time frame: Within 14 days after the cessation of Lacidofil or placebo administration
Occurrence of Clostridium difficile infection
Positive result in Clostridium difficile test: toxin, X-pert, or culture
Time frame: Within 14 days after the cessation of Lacidofil or placebo administration
Total length of hospitalization
the duration from admission to discharge
Time frame: Within 14 days after the cessation of Lacidofil or placebo administration
Duration of antibiotic use
period of antibiotic use during hospitalization + duration of oral antibiotic use after discharge
Time frame: Within 14 days after the cessation of Lacidofil or placebo administration
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