Network Pharmacology Was Applied to Explore the Mechanism of Remimazolam Applied in General Anesthesia for Gynecological Surgeries

Inclusion Criteria: 1. The patient or their family members sign the informed consent form 2. Age: 18-64 years old, BMI: 18-30kg/m2 3. ASA Grade Ⅰ or Ⅱ 4. Patients undergoing gynecological surgeries (laparoscopic total hysterectomy, adnexectomy and myomectomy) Exclusion Criteria: 1. People who are allergic to remimazolam or benzodiazepinesThyroid disease 2. Long-term use of benzodiazepines 3. Pregnancy or lactation 4. Have a history of drug abuse or alcoholism 5. Patients with contraindications for surgery 6. Patients with hypertension (clinically diagnosed with hypertension) and patients with coronary heart disease (with typical angina pectoris symptoms and excluding aortic valve lesions, with a clear history of old myocardial infarction, with a clear history of acute myocardial infarction, and CAG finding coronary artery stenosis greater than or equal to 70%) 7. Patients with arrhythmia, heart failure, renal failure, and those who have recently taken cardiovascular active drugs 8. Endocrine disorders such as hyperthyroidism and pheochromocytoma that may affect the hemodynamic level of the body 9. Patients with ketoacidosis and lactic acidosis 10. Abnormal liver function, ALT\> three times the upper limit of the normal value; 11. Renal failure (serum creatinine \>3mg/dl or creatinine clearance rate \<30ml/min) 12. Patients who have been using sedatives or antidepressants for a long time, or have a history of alcohol abuse or drug dependence 13. Asthma or reactive airway diseases 14. Combined with underlying cognitive function abnormalities 15. Exclusion criteria for research subjects 16. Those who were mistakenly included without meeting the inclusion criteria 17. Those who experienced adverse events such as shock, severe hypotension and severe arrhythmia during the operation