Study on the Surgical Strategy of Corneal Endothelial Protection for Hard Nuclear Cataract Patients

Eye & ENT Hospital of Fudan University207 enrolled

Overview

In this study, we compared two types of phacoemulsification commonly used in cataract surgery to evaluate their effect on the prognosis of patients with hard nuclei. This will provide a theoretical basis for selecting a more appropriate cataract surgery modality in practice in hard-nucleus patients.

In this study, we randomized patients into two groups. One group was the combined mode group in burst mode and the other group was the torsional ultrasound group in continuous mode. Cumulative dissipated energy(CDE) and ultrasound time(UST) were recorded during the procedure. Changes in central cornea thickness(CCT) and endothelial cell density(ECD) of the patients were recorded postoperatively during a 3-month follow-up. Intraoperative and postoperative complications were also recorded. The above data were analyzed to compare the effect of both on postoperative corneal recovery in patients with hard nuclei.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

207

Conditions

Hard Nuclear Cataract Phacoemulsification Cataract Surgery Endothelial Cell Density Loss Central Corneal Thickness

Interventions

combined burst modePROCEDURE

the combined burst mode is commonly used in cataract phacoemulsification. This study compares whether the two modes have different outcomes in hard nuclear cataract surgery.

torsional modePROCEDURE

the toesional mode is commonly used in cataract phacoemulsification. This study compares whether the two modes have different outcomes in hard nuclear cataract surgery.

Eligibility

Sex: ALLMin age: 50 YearsMax age: 95 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with age-related cataracts that were only classified by Emery-Little as nuclear hardness grade III-V. * encompassed a minimum dilated pupil diameter of 7 mm or above, as well as a corneal endothelial cell count exceeding 1200/mm\^2. * Corneal morphology is normal and clear * Informed consent is required prior to enrollment Exclusion Criteria: * Those with white cataracts, histories of eye surgery, and eye diseases such as corneal pathology, uveitis, Fuchs\' dystrophy, and glaucoma were excluded. * Exclude those with comorbid ocular and systemic diseases that affect corneal endothelial cell function * Exclude those with previous intraocular surgery

Locations (1)

Eye and ENT Hospital, Fudan University

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

Endothelial cell density

Endothelial cell density after cataract surgery.

Time frame: At 1day, 1week, 1month, 3months postoperatively.

central cornea thickness

central cornea thickness after cataract surgery.

Time frame: At 1day, 1week, 1month, 3months postoperatively.

ultrasound time

ultrasound time during phacoemulsification.

Time frame: During cataract surgery

cumulative dissipated energy

cumulative dissipated energy during phacoemulsification.

Time frame: During cataract surgery

Secondary Outcomes

best-corrected distance visual acuity

best-corrected distance visual acuity after cataract surgery

Time frame: At 1day, 1week, 1month, 3months postoperatively.

cornea edema

cornea edema after cataract surgery

Time frame: At 1day, 1week, 1month, 3months postoperatively.

occlusion

occlusion during phacoemulsification

Time frame: during surgery

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.