Hyperdynamic Left Ventricular Ejection Fraction as a Predictor of Mortality in Intensive Care Unit Patients With Septic Shock

Ain Shams University235 enrolled

Overview

The study aimed to evaluate the cause and prognosis of hyperdynamic left ventricular ejection fraction in critically ill patients with sepsis.

Cardiovascular dysfunction is increasingly being recognized as a significant complication in sepsis, affecting patient outcomes. Among the key parameters used to evaluate cardiac performance is the left ventricular ejection fraction (LVEF), typically assessed via transthoracic echocardiography (TTE). LVEF has been extensively studied; most investigations into preserved ejection fraction tend to group all values ≥50% together, thereby overlooking the potential clinical implications of LVEF ≥70%, often referred to as hyperdynamic LVEF (HDLVEF).

Study Type

OBSERVATIONAL

Enrollment

235

Conditions

Hyperdynamic Left Ventricular Ejection Fraction Mortality Intensive Care Unit Septic Shock

Interventions

Transthoracic echocardiographyDEVICE

Transthoracic echocardiography (TTE) was carried out. The assessment of left ventricular ejection fraction (LVEF) relied primarily on two-dimensional echocardiography using visual estimation.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age over 18 years. * Both sexes. * Patients who were diagnosed with septic shock. Exclusion Criteria: \- Patients with previously documented abnormal transthoracic echocardiography (TTE) findings, such as severe valvular disease, poor echocardiographic windows, patients admitted to cardiothoracic intensive care unit (ICU), and those not meeting sepsis criteria.

Locations (1)

Ain Shams University

Cairo, Egypt

Outcomes

Primary Outcomes

Intensive care unit mortality

Such patients are admitted to the intensive care unit (ICU), where a definitive diagnosis of sepsis is established using the Sequential Organ Failure Assessment (SOFA) score. This validated scoring system is widely recognized for its ability to predict mortality by evaluating dysfunction across six critical organ systems: respiratory, cardiovascular, hepatic, coagulation, renal, and neurological. The SOFA score is initially calculated upon ICU admission and is subsequently updated every 24 hours, using the most abnormal clinical or laboratory values recorded during the preceding day.

Time frame: 28 days post-procedure

Secondary Outcomes

Discharge against medical advice

Discharge against medical advice was recorded.

Time frame: 28 days post-procedure

Incidence of patients who choose to leave the intensive care unit

Incidence of patients who choose to leave the intensive care unit against medical advice.

Time frame: 28 days post-procedure

Data from ClinicalTrials.gov

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