The aim of this study is to assess the effectiveness of Platelet-Rich Fibrin (PRF) in improving postoperative healing, reducing complications, and enhancing functional outcomes in patients undergoing septoplasty
Septoplasty is a routine surgical intervention to correct nasal septal deviation, a major cause of nasal obstruction and chronic sinusitis. Despite advancements, postoperative complications-such as mucosal injury, synechiae, septal perforation, and hematoma-continue to impact outcomes and patient satisfaction. Platelet-rich fibrin (PRF), first described by Choukroun et al., represents an autologous biomaterial rich in growth factors like PDGF, TGF-β, VEGF, and IGF-1, known to accelerate wound healing and tissue regeneration. Unlike platelet-rich plasma (PRP), PRF is easier to prepare, does not require anticoagulants, and forms a fibrin matrix conducive to sustained release of cytokines. Several studies across disciplines-oral surgery, dermatology, orthopedics-support the regenerative potential of PRF. In nasal surgery, the delicate mucosal environment could benefit significantly from enhanced healing facilitated by PRF.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
SINGLE
Enrollment
100
it is a randomized trial of usage of platelet rich fibrin in septoplasty
Effect of submucoperichondrial application of platelet rich fibrin on healing of nasal septum mucosa after septoplasty
Mucosal Healing will be assessed by visual nasal endscope
Time frame: postoperative at 1st week , 1st month , 3rd month
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