A Clinical Trial to Investigate Efficacy, Safety and Pharmacokinetics (PK) of Two LXE408 Oral Regimens and Oral Miltefosine as Active Control in Participants Aged ≥ 18 Years Old With Localized Cutaneous Leishmaniasis in the Region of the Americas (AMR).

Inclusion Criteria: 1. Participant must be aged ≥18 years old and weighing \> 50kg 2. Participant with first episode of CL fulfilling the following characteristics: * ≤ 6 lesions * At least one lesion of \> 50 mm2 of area * a history of CL of no longer than 6 months 3. a diagnosis of CL confirmed by at least one of the following methods: * microscopic identification of amastigotes in stained lesion tissue, or * demonstration of Leishmania by PCR, or * positive culture for promastigotes 4. In the opinion of the investigator, the participant is capable of understanding and complying with the protocol, including visits up to 6 months after study start. 5. Written informed consent must be obtained before any study protocol specific assessment is performed other than procedures performed as part of standard of care. Participants must be able to give written informed consent. Exclusion Criteria: 1. Female with a positive blood pregnancy test at screening or who is breastfeeding, lactating or women of childbearing potential (defined as women physiologically capable of becoming pregnant) who does not agree to use two methods of contraception, one barrier method and one highly effective method. In Brazil: for 30 days prior to the treatment onset and up to D180 visit. In Panama: during treatment period up to D180 visit. 2. Sexually active male, including those post-vasectomy, unwilling to use a condom during intercourse with female partner while taking the investigational drug and for 5 days, after stopping the investigational drug. 3. Has diagnosis or suspected diagnosis of mucocutaneous, disseminated or diffuse leishmaniasis based on physical exam. 4. Current clinically significant medical problems (e.g., cardiac, renal, hepatic, pancreatic diseases, current cutaneous conditions that may interfere with CL evolution or healing, past and current ocular disorders, especially keratitis, uveitis, scleritis), including any immunocompromising condition (such as having a known diagnosis for HIV, transplanted patients, those in treatment for auto immune diseases, patients receiving immunosuppressant, immunobiological or antineoplastic treatments). 5. History of lymphoproliferative disease or any known malignancy or history of malignancy of any organ system within the past 5 years (except for basal cell carcinoma or actinic keratosis that have been treated with no evidence of recurrence in the past 3 months, carcinoma in situ of the cervix or non-invasive malignant colon polyps that have been removed). 6. Participants newly diagnosed with HIV infection on the basis of the trial screening testing or other recent testing (\< 6 months) are excluded. Participants with documented stable HIV infection are allowed to participate in the study. Stable HIV infection is defined as: clinically stable with no signs or symptoms of advanced HIV infection and taking their current anti-retroviral therapy for ≥ 6 months with an undetectable viral load for ≥ 6 months. Participants taking anti-retroviral therapy prohibited in Section 6.9.4 are excluded. 7. Participants with active infectious conditions, such as tuberculosis, or history or active hepatitis B virus (HBV) infection or hepatitis C virus (HCV) infection are excluded. Active HBV is defined as a positive HBV surface antigen (HBsAg) test, or if standard local practice, a positive HBV core antigen test and all participants with a positive HBV core antibody screening test must have HBsAg measured. Active HCV is defined as having detectable HCV RNA and all participants with a positive HCV antibody test at screening must have HCV RNA measured. Participants taking therapy for HBV or HCV are excluded. 8. ECG abnormalities, either historic (no longer present) or current which, in the view of the investigator, indicate a significant risk to study participation. These include, but are not limited to, the following: * Clinically significant cardiac arrhythmias (e.g., sustained ventricular tachycardia and clinically significant second- or third-degree AV block without a pacemaker). * QTcF ≥450 ms. * History of familial long QT syndrome or known family history of Torsades de Pointes. * Resting heart rate (physical exam or 12 lead ECG) \<60 bpm. 9. Participants who are receiving or have received antileishmanial medication, or prohibited medication or any medication that might interfere with the therapeutic response or cause harmful interactions with study medications, as defined in concomitant treatments in Section 6.9.4. 10. Has laboratory values at screening as follows: Serum creatinine: ≥1.5 times ULN\*, ALT, AST, GGT, ALP: \>1.5 times above upper normal level\*. Total bilirubin \> 1.5 times ULN\* amylase or lipase \> 1.5 times ULN\* \*Normal ranges obtained from local laboratory. 11. Known history of addiction/ alcohol abuse. 12. Hypersensitivity to miltefosine or any study medication excipients. 13. Participants with Sjogren-Larsson Syndrome.