A Clinical Study of the Interactions Between Azvudine Tablets (FNC) and Rilpivirine Tablets (RPV)

Inclusion Criteria: 1. Healthy male or female subjects aged 18 years or older (including 18 years) with an appropriate ratio of male to female participants; 2. The weight of men should be ≥ 50.0kg, and the weight of women should be ≥ 45.0kg. Body mass index (BMI) within the range of 19.0-26.0 (including the critical value).; 3. All fertile male and female subjects agreed to take appropriate and effective physical contraceptive measures from the screening period until the end of the trial, and to use effective physical and/or pharmacological contraceptive measures for 6 months after the trial ends, with no plans for sperm or egg donation; 4. Subjects fully understand the purpose, nature, process of the trial, and the potential adverse reactions, voluntarily agree to participate as subjects, and sign an informed consent form prior to the commencement of all study procedures; 5. Subjects must be able to communicate effectively with the researchers and understand and comply with all requirements of this study. Exclusion Criteria: 1. Individuals with allergic constitutions, a history of drug or food allergies, especially those allergic to any components of this product and its excipients; 2. Individuals with a previous history of hypoglycemia; 3. Individuals who have abnormal results from physical examinations, vital signs check, clinical laboratory tests, 12-lead electrocardiograms, and other pre-trial relevant examinations, deemed clinically significant by the clinical researcher, and considered unqualified (normal reference range for vital signs: systolic blood pressure \<90 mmHg or \>140 mmHg, diastolic blood pressure \<60 mmHg or \>90 mmHg; pulse \<60 bpm or \>100 bpm); 4. Individuals with a history of alcohol abuse within the 12 months prior to screening (consuming ≥14 units of alcohol weekly: 1 unit = 285 ml of beer, or 25 ml of spirits, or 150 ml of wine) or those with positive alcohol breath test results before enrollment (test value \>0 mg/100 ml); 5. Individuals with a history of drug abuse or use of illicit substances within the 12 months prior to screening, including repeated or excessive use of various anesthetics and psychoactive substances, addictive drugs \[MDMA (Ecstasy), Methamphetamine (Ice), Ketamine, Morphine, THC (Marijuana)\] or those with a positive result on the five-panel drug test before enrollment; 6. Individuals who had undergone surgery within 3 months prior to screening, especially those who had surgeries affecting drug absorption, distribution, metabolism, or excretion, or who plan to undergo surgery during the study; 7. Individuals who had used any drug that interacts with the trial medication within 30 days prior to screening, e.g., CYP3A inhibitors (e.g., Itraconazole), CYP3A inducers (e.g., Carbamazepine, Phenytoin, St. John's Wort), proton pump inhibitors (e.g., Rabeprazole), etc.; 8. Individuals with a past medical history of cardiovascular, liver, kidney, pulmonary, gastrointestinal, neurological diseases, particularly any surgical conditions or diseases that might affect drug absorption, distribution, metabolism, and excretion, or conditions that could pose risks to trial participants; 9. Individuals with a history of mental illness (e.g., anxiety, depression); 10. Individuals with febrile illnesses within 3 days prior to screening; 11. Individuals who had participated in other clinical trials and received medication within 3 months prior to screening; 12. Individuals who consumed excessive amounts of tea, coffee, and/or beverages rich in caffeine, theobromine, and alcohol (more than 8 cups, with 1 cup = 250 ml) within 3 months prior to screening; 13. Individuals who had used any prescription medications, over-the-counter drugs, herbal medicines, dietary supplements, and functional vitamins within 14 days before the first dose; 14. Individuals who smoked an average of more than 5 cigarettes daily within 3 months prior to the first dose; 15. Individuals who had donated blood or experienced significant blood loss (greater than 400 ml, excluding normal physiological bleeding in women) within 3 months prior to the first dose, or who planed to donate blood or blood components during the study or within one week after the study; 16. Females who tested positive for pregnancy; pregnant or breastfeeding women; female participants who engaged in unprotected sexual intercourse with a partner within 14 days prior to the trial; 17. Individuals with poor conditions for vascular puncture, or who could not tolerate venous blood sampling, and/or had a history of vasovagal syncope; 18. Individuals who had received a novel coronavirus vaccine within 14 days prior to screening or received any other vaccine within 3 months prior to screening, or planed to receive a vaccine during the study; 19. Individuals deemed unsuitable for this study by the investigator.