Precision Medicine Applied to the Study of Endometrial Cancer: Application of NGS for Molecular Classification

Inclusion Criteria: * Patients over 18 years of age with a diagnosis of EC diagnosed by histological biopsy and surgically treated sequentially in the participating centers in the last 5 years with clinical follow-up. * Patients over 18 years of age, diagnosed with CE III-IV by histological biopsy, not susceptible to surgical treatment in each institution during the last 5 years in clinical follow-up. Cases with a diagnosis of carcinosarcoma (a rare subtype of endometrial carcinoma with sarcomatous transdifferentiation) are included. * Material blocks fixed in formalin and embedded in paraffin with a tumor volume in the paraffin block of at least 1 cm3 Exclusion Criteria: * The following uterine neoplasms will be excluded: * Biphasic tumors (epithelial-mesenchymal) such as adenosarcoma. * Mesenchymal neoplasms such as endometrial stromal sarcoma and leiomyosarcomas. * Others: primary lymphoproliferative processes of the uterine body; neuroendocrine tumors; Gestational trophoblastic disease, secondary lesions either of the genital tract (example: cervical carcinomas with extension to the endometrium) or of distant sites (breast cancer metastasis). * Patients with synchronous endometrial and ovarian carcinoma * For technical reasons, they will be excluded * tumors smaller than 0.2 cm in which sufficient material cannot be obtained for immunohistochemical and molecular biology determinations. * Tumors with severe artifacts due to poor processing, such as autolysis. * Samples with low-quality DNA * Patients operated on outside participating centers. * Patients under 18 years of age. * Patients with primary non-surgical treatments (neoadjuvant chemotherapy).