Biograph Vision 600 Versus Biograph Vision.X PET/CT

Valentina Garibotto40 enrolled

Overview

The main purpose is to evaluate initial clinical experiences and to explore whether the Vision.X system yields improved image quality and diagnostic performance compared to Vision 600.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Cancer Alzheimer Disease

Interventions

ImagesDEVICE

PET/CT images

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Written Inform Consent to participating. * 18 to 85 years of age * Willing and able to comply with the requirements of the study, as judged by the investigator Exclusion Criteria: * Women in pregnancy * Patients unable to lie still for the duration of the examination

Locations (1)

Hopitaux Universitaires de Genève

Geneva, Switzerland

RECRUITING

Outcomes

Primary Outcomes

change of physician's diagnostic confidence

The primary outcome will be image quality assessed on the two compared PET systems, namely Vision and Vision X. For the all PET scans, three independent, blinded physicians will evaluate the scans and establish diagnoses. They will assess the following quality criteria using 5-point Likert scales: * Overall Image Quality: 1 = poor, 5 = excellent, * Image Noise: 1 = excessive noise, 5 = no perceptible noise, Image quality is associated with physician's diagnostic confidence and with the ability to detect smaller lesions that can lead to more accurate staging of diseases, particularly in oncology and neurology. This enhanced staging can influence treatment decisions, allowing healthcare professionals to tailor interventions based on a more precise understanding of the extent and location of the disease.

Time frame: through study completion , an average of 1 year

Secondary Outcomes

lowering of the radiotracer activity

The secondary outcome will be the assessment of image quality (as for the primary outcome) on simulated lower doses of radiotracer activity on both PET systems (Vision and Vision X). To assess this, the same parameters described in section 5.1 will be evaluated across different emulated scan times, as shorter scanning times allow simulating lower administered activities. These will be generated by binning the list-mode data with varying frame durations for both scanner acquisitions. The lowering of the radiotracer activity maintaining a high-quality image is relevant for its capacity to reduce the radiation exposure for the patients and contributes to optimizing healthcare resources.

Time frame: through study completion , an average of 1 year

Central Contacts

Pr Valentina Garibotto Head of the Division of nuclear medicine and molecular imaging, MD

CONTACT

+41223727252 valentina.garibotto@hug.ch

Data from ClinicalTrials.gov

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