Studying the cerebral activity of children with Prader-Willi Syndrom (PWS) when the study propose to them nasal activations.
The present study propose to implement fMRI and olfactory tests to describe olfactory brain activation and olfactory skills in early OT-exposed and non-exposed children with PWS. This study is part of a wider project in collaboration with the team of S. Steculorum at the Max Planck Institute in Germany who assess the architectural and molecular characterization of the olfactory system development in a mice model of PWS and the role of early OT treatment. Moreover, the study will take advantage of the MRI to document the long-term brain connectivity of early OT-exposed and non-exposed children.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
30
the patients have a sniff-test
patients have a an f MRI
University Hospital
Toulouse, France
hyperactivation of the right amygdala in young children with PWS not early OT-exposed and aged between 5 and 7 years in response to a sweet food odor compared to a neutral non-food odor.
intensity of right amygdala in fMRI
Time frame: day 1
hyperactivation of the right amygdala in PWS children stimulated by a sweet food odor vs. a non-food odor compared to non-exposed children.
intensity of right amygdala in fMRI
Time frame: day 1
composite outcome witn an association between olfactory fMRI results and eating behavior in early OT-exposed and non-exposed children with PWS.
scores of the eating beahaviour questionnaires
Time frame: day 1
olfactory skills in early OT-exposed and non-exposed children with PWS.
scores of the sniff test between OT-exposed and non-exposed children.
Time frame: Day 1
resting brain connectivity in early OT-exposed and non-exposed children with PWS.
brain connectivity in fMRI between OT-exposed and non-exposed children.
Time frame: day 1
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