The purpose of this study is to examine the natural history and risk factors of osteoarthritis (OA) and to explore the relationship between metabolic factors and OA progression.
1. To investigate the natural history of osteoarthritis (OA) in a large-sample cohort. 2. To identify OA phenotypes and their relationship with clinical symptoms and functional impairment. 3. To analyze metabolic factors (e.g., obesity, diabetes, and hypertension) as risk factors for OA onset and progression. 4. To evaluate the association between radiographic changes and OA symptoms. 5. To develop predictive models for OA progression and identify high-risk individuals for early intervention. Design: This is a prospective cohort study. Participants: The study will recruit approximately 4,000 individuals aged 50 years and above. Participants will undergo baseline assessments, including demographic data collection, medical history, dietary evaluation, physical examination, blood sample collection, and radiographic imaging. Annual follow-ups will be conducted over 10 years to monitor OA progression and related risk factors.
Study Type
OBSERVATIONAL
Enrollment
4,000
Beijing Tsinghua Chang Gung Hospital
Beijing, Beijing Municipality, China
Incidence of Osteoarthritis
The occurrence of clinically diagnosed osteoarthritis based on imaging and clinical symptoms during the follow-up period.
Time frame: Annually for 10 years
Change in Joint Pain Severity (WOMAC Pain Subscale)
Evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale (range: 0-20). Higher scores indicate worse pain.
Time frame: Annually for 10 years
Change in Physical Function (WOMAC Subscale)
Assessed using the WOMAC physical function subscale (range: 0-68). Higher scores indicate worse physical function.
Time frame: Annually for 10 years
Change in Physical Function (SF-36 Physical Function Domain)
Assessed using the SF-36 physical function domain (range: 0-100). Higher scores indicate better physical function.
Time frame: Annually for 10 years
Timed Up and Go Test (TUGT)
Measured in seconds; a shorter time indicates better mobility.
Time frame: Annually for 10 years
Five Times Sit-to-Stand Test (5TSTS)
Measured in seconds; a shorter time indicates better lower limb strength and function.
Time frame: Annually for 10 years
Radiographic Progression of Osteoarthritis
Measured by changes in Kellgren-Lawrence (K-L) grade in bilateral knee X-rays over time.
Time frame: Annually for 10 years
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Changes in Body Mass Index (BMI)
Measured in kg/m². Analyzed for correlation with radiographic progression of osteoarthritis using the Kellgren-Lawrence grading system.
Time frame: Annually for 10 years
Changes in Blood Pressure
Measured in mmHg using an automated sphygmomanometer to record systolic and diastolic blood pressure.
Time frame: Annually for 10 years
Changes in Fasting Glucose
Measured in mg/dL using venous blood samples collected after an overnight fast.
Time frame: Annually for 10 years
Changes in Total Cholesterol (TC)
Measured in mmol/L or mg/dL using fasting venous blood samples.
Time frame: Annually for 10 years
Changes in Low-Density Lipoprotein Cholesterol (LDL-C)
Measured in mmol/L or mg/dL using fasting venous blood samples.
Time frame: Annually for 10 years
Changes in High-Density Lipoprotein Cholesterol (HDL-C)
Measured in mmol/L or mg/dL using fasting venous blood samples.
Time frame: Annually for 10 years
Changes in Triglycerides (TG)
Measured in mmol/L or mg/dL using fasting venous blood samples.
Time frame: Annually for 10 years