Laparoscopic Sleeve Gastrectomy-Induced Decline in Plasma Asprosin and Its Association With Metabolic Recovery

Northern Jiangsu People's Hospital85 enrolled

Overview

the present study aimed to systematically assess the changes in plasma asprosin levels at 3, 6, and 12 months after LSG, to explore the relationships between asprosin dynamics and key metabolic parameters, including body mass index (BMI), fasting glucose, insulin resistance assessed by the homeostasis model (HOMA-IR), and lipid profiles, and to compare asprosin concentrations between bariatric patients and healthy normal-weight controls.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obesity, Morbid

Interventions

surgeryPROCEDURE

laparoscopic sleeve gastrectomy

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. age between 18 and 65 years; 2. body mass index (BMI) ≥37.5 kg/m², or BMI ≥32.5 kg/m² with at least one obesity-related comorbidity; 3. availability of complete clinical data and stored plasma samples at preoperative baseline and at 3, 6, and 12 months postoperatively. Exclusion Criteria: 1. history of prior bariatric or gastrointestinal surgery; 2. active malignancy, chronic inflammatory or infectious disease, or severe hepatic or renal dysfunction; 3. pregnancy during the study period; 4. incomplete clinical or biochemical data.

Locations (1)

Shuai Zhao

Yangzhou, None Selected, China

Outcomes

Primary Outcomes

Plasma asprosin levels at 3, 6, and 12 months

Time frame: 1 year

Secondary Outcomes

BMI at 3, 6, and 12 months

Time frame: 1 year

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.