For patients with early- to mid-stage hepatocellular carcinoma (HCC), the five-year postoperative recurrence and metastasis rate remains as high as 70%, significantly impacting patient prognosis.Therefore, perioperative therapy may be considered for HCC patients with these high-risk features .
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
130
First, perform a single session of TACE. Followed by three cycles of neoadjuvant therapy with Finotonlimab combined with bevacizumab. Proceed with curative resection. Finally, initiate postoperative adjuvant targeted-immunotherapy . Finotonlimab: intravenously every three weeks ,200mg. bevacizumab:intravenously every three weeks , with a dosage based on body weight: 15 mg (≤60 kg) .
Initial Perform a single session of TACE procedure.TACE treatment is strictly in accordance with the Chinese guidelines for clinical practice of transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (2023 Edition).
Tongji Hospital
Wuhan, Hubei, China
2-year DFS rate and 2-year OS rate
2-year DFS rate refers to the proportion of patients remaining free of disease recurrence or death for over 2 years, measured from the date of surgery. 2-year OS rate refers to the proportion of subjects surviving in the trial cohort at the 2-year follow-up mark, calculated from the initiation of neoadjuvant therapy.
Time frame: 2years
MPR
Defined as the presence of ≥70% tumor necrosis in the tumor bed and regional lymph nodes of resected specimens following curative resection.
Time frame: 9 weeks
pCR
Defined as the absence of viable tumor cells in both the primary tumor site and regional lymph nodes of resected specimens after curative surgery.
Time frame: 9 weeks
R0 rate
The tumor was completely removed with negative margins, meaning no residual tumor
Time frame: 9 weeks
EFS
Event Free Survival
Time frame: 2 years
safety
Safety profiles during neoadjuvant therapy and postoperative period were systematically assessed per CTCAE v5.0
Time frame: 2 years
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