O-RADS MRI System on Early Detection of Ovarian Cancer

Inclusion Criteria: * Patients meeting either of the following criteria based on initial diagnostic pelvic ultrasound findings (pelvic mass or pelvic effusion) suspicious for ovarian malignancy or at elevated risk for ovarian cancer: 1. Postmenopausal women or females ≥45 years with pelvic mass or effusion on ultrasound; 2. Postmenopausal women or females ≥45 years with serum CA125 ≥35 U/mL; 3. Females ≥35 years with a confirmed family history of ovarian or breast carcinoma; 4. Females ≥35 years harboring pathogenic/likely pathogenic BRCA1/2 germline mutations; 5. Females ≥35 years with BRCA1/2 mutations, non-suspicious adnexal lesions on ultrasound but planning prophylactic adnexectomy with availability of serial pathological sectioning. ② Ability to comply with the study protocol and adhere to scheduled follow-up assessments. ③ Provision of written informed consent. Exclusion Criteria: * ① Pregnant individuals * Patients with histopathologically confirmed ovarian cancer * Ovarian malignancy diagnosed by PET-CT at this institution ④ Patients undergoing neoadjuvant chemotherapy for confirmed ovarian cancer ⑤ Claustrophobia precluding tolerance of MRI examination ⑥ Contraindications to MRI: cardiac pacemakers, ferromagnetic implants, or high-risk metallic foreign bodies ⑦ History of gadolinium-based contrast agent (GBCA) hypersensitivity or intolerance ⑧ Severe renal insufficiency (glomerular filtration rate \<30 mL/min/1.73 m²)