Psychiatric disorders characterized by compulsivity, such as obsessive-compulsive disorder (OCD), result in considerable functional impairment and many individuals do not respond to gold-standard treatments. Compulsivity has long been thought to occur due to exaggerated habits and reduced goal-directed control, although more recently, this conceptualization of compulsivity as an imbalance of two cognitive systems has been challenged as overly narrow. This study will recruit 100 individuals (50 adults diagnosed with OCD, 50 healthy controls) and leverage the measurement precision offered by theory-driven computational modeling in combination with electroencephalogram (EEG) to go beyond this binary theory of compulsivity, revealing how more complex interactions of neurocognitive subcomponents contribute to compulsivity-information that could ultimately lead to improved treatment personalization and clinical outcomes.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
100
Exposure and response prevention (EX/RP) is the gold-standard behavioral treatment for OCD. It involves confronting the content of obsessions (distressing thoughts, images, or impulses) and resisting the urge to engage in compulsions (observable behaviors or mental acts that are repeated to reduce the anxiety/distress associated with compulsions).
Icahn School of Medicine at Mount Sinai
New York, New York, United States
RECRUITINGYale Brown Obsessive Compulsive Scale
A semi-structured clinician-administered instrument used to measure obsessions and compulsions separately over five dimensions (time consumed, distress, interference, degree of resistance, control). The range of scores for the Obsessions and Compulsions subscales is 0-20, and the range for the total score is 0-40. Higher scores indicate greater symptom severity, and a total score greater or equal to 16 is considered indicative of moderately severe OCD
Time frame: Week 1, Week 5, Week 10
Obsessive Compulsive Inventory- Revised
An 18-item self-report measure to assess obsessions and compulsions that demonstrates good psychometric properties and has been used in other research as a transdiagnostic measure of compulsivity. The range of scores for the six subscales (Washing; Obsessing; Ordering; Checking; Neutralizing; Hoarding) is 0-12. The range for the total score is 0-60 and does not include the Hoarding subscale. Higher scores indicate greater symptom severity.
Time frame: Week 1, Week 5, Week 10
Cambridge-Chicago Compulsivity Trait Scale
A 15-item self-report measure to assess compulsivity transdiagnostically that exhibits high internal consistency and excellent convergent validity with gold-standard measures of compulsive symptoms. The range for the total score is 0-45, with higher scores indicating greater symptom severity
Time frame: Week 1, Week 5, Week 10
Self-Report Habit Index
A 12-item self-report measure of the repetition and automaticity of a behavior that exhibits high internal consistency and test-retest reliability. The range for the total score is 12-84, with higher scores indicating greater symptom severity.
Time frame: Week 1, Week 5, Week 10
Dimensional Obsessive- Compulsive Scale
A 20-item self-report measure that assesses four of the most consistently replicated thematic dimensions of OCD symptoms (i.e., contamination, harm, symmetry, repugnant content). The DOCS demonstrates good to excellent internal consistency, validity, and sensitivity. The range of scores for the four subscales (Contamination; Harm; Unacceptable Thoughts; Symmetry) is 0-20, and the range for the total score is 0-80. Higher scores indicate greater symptom severity.
Time frame: Week 1, Week 5, Week 10
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