The primary objective of this study is to investigate the effects of BPN14770 on the pharmacokinetics of the breast cancer resistance protein and organic anion transporting polypeptide 1B1 substrate rosuvastatin in healthy adults.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
12
Oral tablet
Oral capsule
ICON Clinical Research
Lenexa, Kansas, United States
Maximum Plasma Concentration (Cmax) of Rosuvastatin
Time frame: Days 1 and 11 (pre-dose, up to 72 hours post-dose)
Time to Maximum Plasma Concentration (Tmax) of Rosuvastatin
Time frame: Days 1 and 11 (pre-dose, up to 72 hours post-dose)
Cmax of BPN14770
Time frame: Day 11 (pre-dose, up to 72 hours post-dose)
Tmax of BPN14770
Time frame: Day 11 (pre-dose, up to 72 hours post-dose)
Cmax of Coproporphyrin I
Time frame: Days 1 and 11 (pre-dose, up to 72 hours post-dose)
Tmax of Coproporphyrin I
Time frame: Days 1 and 11 (pre-dose, up to 72 hours post-dose)
Number of Participants Experiencing Treatment-emergent Adverse Events
Time frame: Day 1 through Day 21
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