Sarcopenia and Intervention Physical Therapy

N/ANot Yet RecruitingNCT07013604

Pharos University in Alexandria60 enrolled

Overview

To evaluate and compare the effectiveness of neuromuscular electrical stimulation (NMES) and low-load resistance training with blood flow restriction (BFR) in improving muscle mass, strength, functional performance, and quality of life in elderly individuals diagnosed with sarcopenia

Sarcopenia, the age-related decline in muscle mass, strength, and function, significantly affects the health and independence of elderly individuals. It increases the risk of frailty, falls, and disability. Neuromuscular electrical stimulation (NMES) and low-load resistance training with blood flow restriction (BFR) are promising rehabilitation strategies for older adults with limited physical capacity. This study aims to compare the effectiveness of NMES and BFR in managing sarcopenia and improving physical and functional outcomes in the elderly

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Sarcopenia

Interventions

Neuromuscular Electrical Stimulation (NMES) Group,Resistance + BFR GroupDEVICE

NMES Group: Receives neuromuscular electrical stimulation to the thigh muscles for 30 minutes, three times per week, over 8 weeks. Resistance + BFR Group: Performs low-load resistance exercises with blood flow restriction applied to the thighs, also for 30 minutes per session, three times per week, over 8 weeks. Control Group: Receives placebo treatment using a turned-off stimulation device with no active intervention during the 8-week period.

Eligibility

Sex: ALLMin age: 60 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Older age (≥ 60-75 years) Low muscle strength (e.g., low handgrip strength) Low muscle mass (e.g., ASM/height² below cutoff) Exclusion Criteria: * heart disese * kidny disese * autoimune disese * cognetive disorder * sever form of sarcopenia

Outcomes

Primary Outcomes

Change in Muscle Mass

Assessed using Bioelectrical Impedance Analysis (BIA) to measure skeletal muscle mass. Evaluation is done pre- and post-intervention to detect changes in the Skeletal Muscle Index (SMI), based on EWGSOP2 criteria

Time frame: 2 month

Secondary Outcomes

Muscle Strength Handheld dynamometer (e.g., MicroFET)

Isometric knee extension strength Measurement: Pre- and post-intervention, using the highest or average value from 2-3 trials.

Time frame: 2 month

Timed Up and Go (TUG) Test

Assesses eight domains of health-related quality of life, scored from 0 to 100. Administered before and after the intervention period

Time frame: 2 month

Data from ClinicalTrials.gov

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