We Analyse Metabolites in Dried Blood Spots From Newborns That Later in Life Developed an Eating Disorder.

N/AActive Not RecruitingNCT07016334

Karolinska Institutet3,000 enrolled

Overview

Anorexia nervosa (AN) and bulimia nervosa (BN) are serious eating disorders (EDs) with significant morbidity and mortality. Genetic studies have shown associations between EDs and metabolic traits, and longitudinal studies indicate distinct weight trajectories in children who later develop AN or BN, suggesting early involvement of metabolic factors. Biological studies also reveal differences in immune and neurotrophic markers in individuals with EDs compared to controls. Intriguingly, metabolites measured in neonatal blood could serve as very early markers of ED risk, unconfounded by state or scar factors related to prolonged starvation. Here the investigators propose to comprehensively analyze neonatal biomarkers (metabolic, immune, and neurotrophic), epidemiological factors, and genetics to understand ED risk and develop risk prediction models

Study Type

OBSERVATIONAL

Enrollment

3,000

Conditions

Eating Disorders

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: \- in PKU-register with or withou life-time diagnosis of anorexia or bulimi nervosa Exclusion Criteria: * not in PKU register

Locations (1)

Karolinska Institutet

Stockholm, Sweden

Outcomes

Primary Outcomes

Metabolomic factors measured by mass-spectrometry

Metabolomic factors such as amino acids, sugars, lipids, and organic acids extracted from dried blood spots sampled at birth are measured by mass spectrometry

Time frame: Sampled at birth (day 1)