The primary purpose of this study is to assess the pharmacokinetics (PK) of BPN14770 after a single oral administration of BPN14770 in participants with mild, moderate, and severe liver impairment compared with control participants with normal hepatic function.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
32
Administered as specified in the treatment arm.
Division of Clinical Pharmacology, University of Miami
Miami, Florida, United States
Orlando Clinical Research Center
Orlando, Florida, United States
Texas Liver Institute
San Antonio, Texas, United States
Area Under the Plasma Concentration Time Curve Extrapolated from Time 0 to Infinity (AUCinf) of BPN14770
Time frame: Predose up to 240 hours postdose
Maximum Observed Plasma Concentration (Cmax) of BPN14770
Time frame: Predose up to 240 hours postdose
Time Maximum Observed Plasma Concentration (Tmax) of BPN14770
Time frame: Predose up to 240 hours postdose
Number of Participants With Treatment Emergent Adverse Events (TEAEs)
Time frame: Up to 15 days postdose
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